Key takeaways
Vilazodone (Viibryd) and bupropion (Wellbutrin XL) are both medications used to treat depression, but they work in different ways and have distinct characteristics. Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a serotonin (5HT1A) receptor partial agonist, while bupropion is an atypical antidepressant that boosts norepinephrine and dopamine levels in the brain. Vilazodone is typically taken once daily with food, whereas bupropion is available in short-acting forms taken multiple times a day or long-acting forms taken once daily. Bupropion is also approved to treat seasonal affective disorder (SAD), unlike vilazodone. Vilazodone is less likely to cause weight gain and sexual side effects compared to other antidepressants, while bupropion is also known for having fewer sexual side effects and is less likely to cause weight gain. However, bupropion is not suitable for people with a history of eating disorders. Both medications can cause withdrawal symptoms if stopped suddenly and may take several weeks to show full effects.
