Key takeaways
Vicodin (hydrocodone/acetaminophen) and Percocet (oxycodone/acetaminophen) are both combination medications used to treat pain when non-opioid medications aren't effective. The main difference between the two is the type of opioid they contain: Vicodin has hydrocodone, while Percocet has oxycodone. Studies suggest that both medications are generally effective for pain relief, but hydrocodone may cause less nausea and dizziness compared to oxycodone, while oxycodone might cause less constipation. Both medications carry a high risk of misuse, dependency, and addiction, and they are controlled substances under the Opioid Analgesic REMS program. Vicodin is no longer available under its brand name in the United States, but generic versions are still available. Both medications can cause serious side effects like dangerously slow breathing, liver damage, and withdrawal symptoms if not taken as prescribed. Always discuss with your healthcare provider to determine which medication is best for your pain management needs.
