Key takeaways
Cefpodoxime and ceftibuten are both cephalosporin antibiotics used to treat bacterial infections. They are similar in that they both belong to the third-generation cephalosporin class and work by preventing bacteria from forming a protective covering. However, there are several differences between the two medications. Cefpodoxime is available as a generic and can be taken as a tablet or liquid suspension, while ceftibuten, known by the brand name Cedax, is no longer available in the U.S. Cefpodoxime is FDA-approved for a wider range of infections, including urinary tract infections, pneumonia, and gonorrhea, whereas ceftibuten was used for lung, ear, and throat infections. Cefpodoxime is typically taken twice a day, while ceftibuten was taken once daily. Common side effects of cefpodoxime include diarrhea and nausea, and it can interact with medications like antacids. Ceftibuten's discontinuation was not due to safety or effectiveness concerns, but its unavailability limits its use compared to cefpodoxime.
