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Valium vs. Chlordiazepoxide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Diazepam (Valium) and chlordiazepoxide (Librium) are both benzodiazepines used to treat anxiety and alcohol withdrawal symptoms. Diazepam is available as a tablet and liquid solution, while chlordiazepoxide comes as a capsule. Diazepam works by increasing levels of gamma-aminobutyric acid (GABA) in the brain, which helps control anxiety, muscle spasms, and seizures. On the other hand, researchers aren't exactly sure how chlordiazepoxide works, but it's thought to slow down brain activity to manage anxiety and alcohol withdrawal symptoms. Diazepam typically starts working within 15 to 30 minutes, whereas chlordiazepoxide can take up to 4 hours to reach maximum levels in your blood. Both medications carry a risk of addiction and dependence, and they should be used for the shortest time possible. Both medications are not recommended during pregnancy or breastfeeding. Common side effects for both include drowsiness, dizziness, and confusion.

Diazepam

(Valium)

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Chlordiazepoxide

 

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Summary for Valium

Prescription only

Diazepam (Valium) is a benzodiazepine. It's used to treat symptoms of anxiety and alcohol withdrawal. It can also treat certain types of muscle spasms and seizures. Diazepam (Valium) comes as a tablet and liquid solution. It's taken by mouth, typically 2 to 4 times daily. Some common side effects of diazepam (Valium) include sleepiness, dizziness, and weakness. Additionally, this medication carries a risk for misuse and dependence, so it's classified as a controlled substance.

Indications for Valium

Pros and Cons for Valium

Pros

  • Taken by mouth
  • Available as tablets and liquid
  • Works within 30 minutes

Cons

  • Might need to take multiple times a day
  • Short-term use only because risk for dependence
  • Generally not recommended during pregnancy or breastfeeding

Common Side Effects for Valium

  • Sleepiness
  • Dizziness
  • Muscle weakness
  • Problems with balance or coordination
  • Memory problems

Warnings for Valium

  • Extreme sleepiness and difficulty breathing
  • Misuse and dependence
  • Withdrawal
  • Harm to babies during pregnancy and after delivery
  • Interactions with other medications
  • Use with caution in people with depression

Summary for Chlordiazepoxide

Prescription only

Chlordiazepoxide is used for the short-term relief of anxiety symptoms. It can also prevent alcohol withdrawal symptoms, like seizures. This medication has a risk of addiction, so it's classified as a schedule IV controlled substance. Your dose will depend on the reason why you're using it, your age, and your other health conditions. Some possible side effects of chlordiazepoxide include drowsiness, trouble with balance and movement, and confusion. Chlordiazepoxide comes as a capsule, and is available as a brand name and a lower-cost generic.

Indications for Chlordiazepoxide

  • Alcohol withdrawal
  • Preoperative anxiety and anxiety disorders

Pros and Cons for Chlordiazepoxide

Pros

  • Available as a lower-cost generic
  • A first-choice treatment option for alcohol withdrawal
  • Can be used in children age 6 and older
  • Dose can be adjusted by your provider based on your response

Cons

  • Controlled medication due to the risk of addiction, misuse, and dependence
  • Risk of more side effects in older adults
  • Can cause withdrawal if suddenly stopped
  • Should only be used short-term

Common Side Effects for Chlordiazepoxide

  • Drowsiness
  • Confusion
  • Loss of coordination (clumsiness)

Warnings for Chlordiazepoxide

  • Risks while also taking opioids
  • Potential for addiction, misuse, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies

Prices with our coupons for Valium vs. Chlordiazepoxide

Price Card Drug Icon
Diazepam30 tablets / 5mg
$10.43$22.04
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Chlordiazepoxide15 capsules / 25mg
$7.64$13.91
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