Tyrvaya vs. Restasis for Dry Eye: Important Differences and Potential Risks.

Tyrvaya

(varenicline)

Cyclosporine

(Restasis)

Summary for Tyrvaya

Prescription only

Tyrvaya (varenicline) is a cholinergic agonist. It's a nasal spray used to treat dry eye in adults. This medication is sprayed into each nostril, typically twice a day. Some side effects of Tyrvaya (varenicline) include sneezing, cough, and throat irritation.

Indications for Tyrvaya

Dry eye

Pros and Cons for Tyrvaya

Pros

Can relieve dry eyes in as quickly as 5 minutes
Can cause eyes to make 50% more tears after a month of treatment
Can be stored at room temperature

Cons

Must be used twice a day and in each nostril
Brand name only
Commonly causes sneezing as a side effect

Common Side Effects for Tyrvaya

Sneezing (82%)
Cough (16%)
Throat irritation (13%)
Nose irritation (8%)

Summary for Restasis

Prescription only

Cyclosporine eye drops, also known by the brand names Restasis and Restasis MultiDose, treat dry eye in people 16 years and older. It's an immunosuppressant called a calcineurin inhibitor, and it helps with tear production. Cyclosporine (Restasis) comes in single-use vials and multi-dose bottles. Only the single-use vials have a generic version. The eye drops are used twice every day. The most common side effect is a burning feeling in the eye, which usually gets better as you continue to use the medication.