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Cyclosporine Coupon - Cyclosporine 60 vials of 0.4ml package

cyclosporine

Generic Restasis
Used for Dry Eye
Used for Dry Eye

Cyclosporine eye drops, also known by the brand names Restasis and Restasis MultiDose, treat dry eye in people 16 years and older. It's an immunosuppressant called a calcineurin inhibitor, and it helps with tear production. Cyclosporine (Restasis) comes in single-use vials and multi-dose bottles. Only the single-use vials have a generic version. The eye drops are used twice every day. The most common side effect is a burning feeling in the eye, which usually gets better as you continue to use the medication.

Last reviewed on February 26, 2025
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What is Cyclosporine (Restasis)?

What is Cyclosporine (Restasis) used for?

  • Dry eye in people 16 years and older

How Cyclosporine (Restasis) works

Cyclosporine (Restasis) is a type of immunosuppressant called a calcineurin inhibitor. The medication stops a protein called calcineurin from working. It lowers inflammation in the eye, which helps your eye make more tears.

Are you looking for information on Cequa (cyclosporine), Vevye (cyclosporine), or Verkazia (cyclosporine) instead?
When does Cyclosporine (Restasis) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsRestasis, Restasis MultiDose
Drug ClassImmunosuppressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Cyclosporine (Restasis) essentials

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Avg retail price
$606.470
GoodRx discount
$606.47
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What are the side effects of Cyclosporine (Restasis)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Burning sensation in the eye (17%)

Other Side Effects

  • Eye redness
  • Eye discharge
  • Watery eye
  • Eye pain
  • Feeling like there's something in the eye
  • Itchy eye
  • Stinging in the eye
  • Eye swelling
  • Blurry vision
When do Cyclosporine (Restasis) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Burning sensation in the eye
Itchy eye
Eye swelling and redness
Eye discharge

Source: DailyMed

More on Cyclosporine (Restasis) side effects

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Change in your skin, such as a new growth, a sore that doesn't heal, or a change in a mole
  • Dizziness, loss of balance or coordination, confusion or trouble speaking
  • Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Increase in blood pressure
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cyclosporine (Restasis)

thumbs-up

Pros

Helps your eye make its own tears

Can use with other lubricating eye drops, such as artificial tears

Available as single-use vials and multi-dose bottles

thumbs-down

Cons

Need to use twice a day

Can take a long time (up to 6 months) to see improvement in dry eyes

Commonly causes a burning sensation in the eye

pharmacist-tips

Pharmacist tips for Cyclosporine (Restasis)

pharmacist
  • Put cyclosporine (Restasis) into the affected eye(s) twice a day, about 12 hours apart. If you use other eye drop medications too, wait at least 15 minutes between each medication. This gives your eye time to absorb each medication properly.

    • Take out your contact lenses from your eye(s) before you use cyclosporine (Restasis). Wait at least 15 minutes before you put your lenses back into your eye(s). Ask your eye specialist if you should keep wearing contact lenses or switch to glasses since contacts can sometimes make dry eye worse.

      • Wash your hands before you put cyclosporine (Restasis) drops in your eye(s). Don't touch the dropper tip with your hands, and don't let the tip touch your eye or any other surface. This helps prevent eye infections by lowering the risk of contaminating the medication. You might get prescribed two bottles of cyclosporine (Restasis), one for each eye, to lower the risk of contamination.

        • Tilt your head backward and look up. Gently pull your bottom eyelid down to make a small pocket. Then, hold the cyclosporine (Restasis) bottle upside down right above the eye. Squeeze the bottle so that 1 drop of medication falls into the pocket. Close your eye. Then, press a finger against the inside corner of your eye for about a minute to help keep the medication in your eye.

          • Throw away the 0.4 mL single-use vials after placing the drop in your eye(s). Don't save any leftover medication. Use each single-use vial just once. They don't have a cap that you can put back on like the Restasis MultiDose bottles do.

            • Store cyclosporine (Restasis) at room temperature (between 59 and 77 degrees Fahrenheit). Keep the medication in the original package to protect it from light.

              • Each time you use a new bottle of Restasis MultiDose, prime the bottle before you put any of the medication into the eye(s). Take off the olive green cap and squeezing two drops of medication onto a tissue. Don't let the tip of the bottle touch the tissue.

                • Before using Restasis MultiDose, turn the bottle upside down a few times. This makes sure the medication is mixed well. Don't shake the bottle really hard.

                  • After each time you use Restasis MultiDose, put the green cap back on the bottle until you need to use it again. The cap helps prevent germs from getting into the medication.

                    More on Cyclosporine (Restasis) tips

                    faqs

                    Frequently asked questions about Cyclosporine (Restasis)

                    How long does it take for cyclosporine (Restasis) to work?
                    In studies, it took about 6 months for people using cyclosporine (Restasis) to see improvement in their dry eye. But those with milder symptoms might feel some relief within a month. Talk to your prescriber if you have questions about how fast the medication is working. You can also ask about other options to try as you wait for cyclosporine (Restasis) to work.
                    Is cyclosporine (Restasis) over the counter?
                    No. Cyclosporine (Restasis) is only available with a prescription from a healthcare professional (HCP). But there are over-the-counter (OTC) options for dry eye available. OTC options like artificial tears might work faster to relieve dry eye, but they don't last very long. Also, the FDA recommends using OTC eye drops for dry eye for up to 3 days before asking an HCP for more help. Don't use OTC eye drops in place of cyclosporine (Restasis) unless your prescriber said you can.
                    Can cyclosporine (Restasis) make dry eye worse?
                    No, cyclosporine (Restasis) won't make dry eye worse. It works to improve dry eye. But using other eye drops, like over-the-counter artificial tears, often or for a long time sometimes can. This is especially true if the eye drops have preservatives. Talk to your prescriber if your dry eye doesn't get better after starting cyclosporine (Restasis).
                    Will the burn from cyclosporine (Restasis) eye drops go away?
                    Yes. Having a burning feeling in the eye is the most common side effect of cyclosporine (Restasis). But it should get better and eventually go away as you continue to use the medication. Tell your prescriber or eye specialist if the burning feeling bothers you too much or if it doesn't go away.
                    What's the difference between Xiidra and Restasis?
                    Xiidra and Restasis are both eye drops that are used twice a day to treat dry eye. But they're different medications. They work in different ways to lower inflammation and relieve dry eye. Some people might feel improvement after about 2 weeks of using Xiidra. But for people using Restasis, they might feel relief after at least a month. These two medications haven't been directly compared, so it's not clear which one works better. But studies show that both can help with dry eye. Talk to your eye specialist if you have questions about which medication is best for you.
                    Is cyclosporine (Restasis) a steroid?
                    No, cyclosporine (Restasis) isn't a steroid medication. It's a type of medication called a calcineurin inhibitor. Cyclosporine (Restasis) and some steroid eye drops, like Eysuvis (loteprednol), work in different ways to reduce inflammation related to dry eye.
                    How many times can you use a vial of cyclosporine (Restasis)?
                    Use each single-use vial of cyclosporine (Restasis) one time only. After you open it and place a drop into the eye(s), throw away the vial even though there'll be some medication left. Single-use vials don't have a cap to put back on, so there's a higher chance of germs getting into the medication. This isn't the case for Restasis MultiDose, which you can use many times until it expires. Just make sure to put the cap back on the MultiDose bottle after each use.
                    Is there a generic for cyclosporine (Restasis)?
                    The Restasis 0.4 mL single-use vial is available as a generic. But there's no generic for the Restasis MultiDose 10 mL bottle; the MultiDose is only brand name right now.
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                    What are the risks and warnings for Cyclosporine (Restasis)?

                    Cyclosporine (Restasis) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    For use in the eye only

                    Cyclosporine (Restasis) is an eye drop medication that you should place onto the surface of the eye only. Don't put cyclosporine (Restasis) on or into any other place on your body.

                    risk-warning

                    Avoid use with contact lenses

                    Don't place cyclosporine (Restasis) in the eye while you're wearing contact lenses. If you wear contact lenses, take them out before using this medication. You can put your contact lenses back in 15 minutes after using cyclosporine (Restasis).

                    In general, people with dry eye shouldn't wear contact lenses because having lenses in can make the dryness worse. Ask your eye specialist if you should wear glasses or contact lenses while you're being treated for dry eyes.

                    dosage

                    Cyclosporine (Restasis) dosage forms

                    The average cost for 1 package of 60 vials of 0.4ml of Cyclosporine (Restasis) is $631.21 with a free GoodRx coupon. This is 18.68% off the average retail price of $776.17.
                    bottle of solution
                    Bottle of solution
                    DosageQuantityPrice as low asPrice per unit
                    5.5ml of 0.05%1 bottle$630.43$630.43
                    package
                    Package
                    DosageQuantityPrice as low asPrice per unit
                    30 vials of 0.4ml2 packages$631.58$315.79
                    60 vials of 0.4ml1 package$631.21$631.21

                    Typical dosing for Cyclosporine (Restasis)

                    Restasis, Restasis MultiDose, and generic cyclosporine eye emulsion contain 0.05% of medication.

                    The typical dose is 1 drop in affected eye(s) twice a day about 12 hours apart.

                    More on Cyclosporine (Restasis) dosage forms

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                    alternatives

                    What are alternatives to Cyclosporine (Restasis)?

                    There are a number of medications that your doctor can prescribe in place of Cyclosporine (Restasis). Compare a few possible alternatives below.
                    Cyclosporine (Restasis)
                    Used for:
                    • Dry eye in people 16 years and older

                    $606.47 Lowest GoodRx priceView Prices
                    Used for:
                    • Dry eyes

                    $679.75 Lowest GoodRx priceView Prices
                    Used for:
                    $547.72 Lowest GoodRx priceView Prices
                    latest news

                    What is the latest news about Cyclosporine (Restasis)?

                    images

                    Cyclosporine (Restasis) images

                    white - Cyclosporine 0.05% Ophthalmic Emulsion
                    This medicine is White Package.white - Cyclosporine 0.05% Ophthalmic Emulsion
                    white - Cyclosporine 0.05% Ophthalmic Emulsion
                    This medicine is White Package.white - Cyclosporine 0.05% Ophthalmic Emulsion

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                    References

                    Best studies we found

                    Allergan, Inc. (2024). RESTASIS- cyclosporine emulsion [package insert]. DailyMed.

                    Allergan, Inc. (2024). RESTASIS MULTIDOSE- cyclosporine emulsion [package insert]. DailyMed.

                    Apotex Corp. (2024). CYCLOSPORINE emulsion [package insert]. DailyMed.

                    View All References (2)

                    Code of Federal Regulations. Part 349—Ophthalmic drug products for over-the-counter human use. National Archives.

                    Safarini, O. A., et al. (2023). Calcineurin inhibitors. StatPearls.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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