Vevye
Vevye (cyclosporine) is a prescription eye drop that treats signs and symptoms of dry eyes. It's a preservative-free medication that has been shown to work after 4 weeks. You need to use it twice per day, about 12 hours apart. Common side effects include changes in vision and instillation site reactions like eye irritation or burning and stinging in the eye.
What is Vevye (cyclosporine)?
What is Vevye (cyclosporine) used for?
Dry eyes in adults
How Vevye (cyclosporine) works
Vevye (cyclosporine) is a calcineurin inhibitor. By stopping a protein called calcineurin from working, Vevye (cyclosporine) lowers inflammation in your eyes, which helps your eyes to make tears.
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What are the side effects of Vevye (cyclosporine)?
Common Side Effects
- Instillation-site reactions (e.g., eye irritation, burning and stinging in the eye) (8%)
- Lower vision sharpness (3%)
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- New or worsening eye pain, redness, irritation, or discharge
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Blurry vision
- Eye irritation or itching
Pros and cons of Vevye (cyclosporine)
Pros
Shown to work after 4 weeks
Is a preservative-free eye drop
Cons
Needs to be taken twice per day
Might be difficult for some people to administer correctly
Pharmacist tips for Vevye (cyclosporine)
Make sure you know how to use the Vevye (cyclosporine) eye drops to avoid accidentally hurting yourself or wasting any of the medication. Ask your provider or pharmacist if you have any questions.
How to use eye drops: First, wash your hands with soap and water. Then, hold Vevye (cyclosporine) near your eyelid. Tilt your head backward and look up. Gently pull your lower eyelid down to form a small pocket and squeeze one drop of medication into this pocket. Close your eyes gently while pressing a finger against the inside corner of your eye for about 1 minute to help keep the medication in your eye.
If you get blurry vision or if your eyes become sensitive to light after using Vevye (cyclosporine), don't drive or operate machinery until these side effects go away.
The bottle and tip of Vevye (cyclosporine) must stay clean and free of bacteria. Don't touch the tip with your hands, to your eye, or to any other surface when using the eye drops. If you do, bacteria can get into the bottle or on the bottle tip, which may contaminate it. Using the medication afterwards can then cause eye infections.
Make sure to keep the Vevye (cyclosporine) bottle capped and closed tightly when you're not using it.
Don't share Vevye (cyclosporine) with anyone to prevent contamination from other people.
Store Vevye (cyclosporine) in a cool and dry place at room temperature in its original container with the cap on and keep it away from children. Don't put it in the refrigerator or the freezer.
Frequently asked questions about Vevye (cyclosporine)
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What are the risks and warnings for Vevye (cyclosporine)?
Vevye (cyclosporine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Eye injury or infection
Don't let the tip of the bottle touch the eye, eyelid, fingers, or other surfaces. Doing so can contaminate Vevye (cyclosporine) and cause serious harm to the eye, such as infection and vision loss.
Use with contact lenses
Don't use Vevye (cyclosporine) drops when you have your contacts in. Take your contacts out before you use this medication. You can put your contacts back in after waiting at least 15 minutes.
Vevye (cyclosporine) dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 2ml of 0.1% | 1 eye dropper | $299.00 | $299.00 |
Typical dosing for Vevye (cyclosporine)
The typical dose is 1 drop in each eye twice a day, about 12 hours apart.
How much does Vevye (cyclosporine) cost?
What are alternatives to Vevye (cyclosporine)?
Dry eye in people 16 years and older
Vevye (cyclosporine) images
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References
Best studies we foundCequa (cyclosporine ophthalmic solution) 0.09%. (n.d.). Unique ncell® technology and formulation provide superior delivery over cyclosporine emulsion 0.05%.
Golden, M. I., et al. (2023). Dry eye syndrome. StatPearls.
Holland, E. J., et al. (2019). Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature review. The Ocular Surface.
Masters, J. S., et al. (2023). Vernal keratoconjunctivitis. American Academy of Ophthalmology EyeWiki.
Novaliq GmbH. (2023). Vevye- cyclosporine ophthalmic solution solution/ drops [package insert]. DailyMed.
Novaliq Transforming Ocular Therapeutics. (n.d.). Novaliq announces food and drug administration approval of vevye™ (cyclosporine ophthalmic solution) 0.1%, for the treatment of the signs and symptoms of dry eye disease.
Safarini, O. A., et al. (2022). Calcineurin inhibitors. StatPearls.
SafeMedication. (n.d.). How to use eye drops.
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