Key takeaways
Vevye (cyclosporine) and Miebo (perfluorohexyloctane) are both prescription eye drops used to treat dry eyes in adults. However, they belong to different medication classes and work in distinct ways. Vevye is a calcineurin inhibitor that reduces inflammation to help your eyes produce more tears, while Miebo is a semifluorinated alkane that forms a protective layer to prevent tears from evaporating. Vevye is typically used twice a day, whereas Miebo needs to be applied four times daily. Vevye is available only as a brand-name medication, while Miebo is also brand-name only. Common side effects of Vevye include eye irritation and changes in vision, while Miebo may cause blurred vision and eye redness. Both medications require you to remove contact lenses before use, but you should wait at least 15 minutes before reinserting them with Vevye and 30 minutes with Miebo.
