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Compare Xiidra vs. Restasis

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Xiidra (lifitegrast)
    Cyclosporine (Restasis)
  • Xiidra (lifitegrast)
    Cyclosporine (Restasis)

  • Summary of Xiidra vs. Restasis

    Summary for LFA-1 antagonist
    Prescription only

    Xiidra (lifitegrast) is an eye drop medication that treats dry eye in adults. It belongs to a drug class called LFA-1 antagonists. It's thought help lower inflammation and other symptoms of dry eye. Usually, you need to use Xiidra (lifitegrast) every day. You put 1 drop into each eye twice a day. Side effects include temporary eye irritation and unclear vision. At this time, Xiidra (lifitegrast) is available only as a brand medication. There's no generic version yet.

    Summary for Immunosuppressant
    Prescription only

    Cyclosporine eye drops, also known by the brand names Restasis and Restasis MultiDose, treat dry eye in people 16 years and older. It's an immunosuppressant called a calcineurin inhibitor, and it helps with tear production. Cyclosporine (Restasis) comes in single-use vials and multi-dose bottles. Only the single-use vials have a generic version. The eye drops are used twice every day. The most common side effect is a burning feeling in the eye, which usually gets better as you continue to use the medication.

  • Indications of Xiidra vs. Restasis

    Indications for
    •Dry eye
    Indications for
    •Dry eye in people 16 years and older

  • Pros and Cons of Xiidra vs. Restasis

    Pros and Const for LFA-1 antagonist
    Pros
    •Works to help treat dry eye in the long run
    •Might be less likely to cause burning in the eyes than Restasis (cyclosporine)
    Cons
    •Won't give you instant relief and have to take for a couple weeks before it starts working
    •Not approved for people younger than 17 years old
    Pros and Const for Immunosuppressant
    Pros
    •Helps your eye make its own tears
    •Can use with other lubricating eye drops, such as artificial tears
    •Available as single-use vials and multi-dose bottles
    Cons
    •Need to use twice a day
    •Can take a long time (up to 6 months) to see improvement in dry eyes
    •Commonly causes a burning sensation in the eye

  • Common Side Effects of Xiidra vs. Restasis

    Common Side Effects for
    •Eye irritation (5-25%)
    •Strange taste in the mouth (5-25%)
    •Unclear vision (5-25%)
    Common Side Effects for
    •Burning sensation in the eye (17%)

  • Warnings of Xiidra vs. Restasis

    Common Side Effects for
    •Risk of contamination
    Common Side Effects for
    •For use in the eye only
    •Avoid use with contact lenses

  • Prices with our coupons for Xiidra vs. Restasis

    Learn more about Xiidra
    Learn more about Cyclosporine

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