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Compare Tyrvaya vs. Xiidra

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Tyrvaya (varenicline)
    Xiidra (lifitegrast)
  • Tyrvaya (varenicline)
    Xiidra (lifitegrast)

  • Summary of Tyrvaya vs. Xiidra

    Summary for Cholinergic agonist
    Prescription only

    Tyrvaya (varenicline) is a cholinergic agonist. It's a nasal spray used to treat dry eye in adults. This medication is sprayed into each nostril, typically twice a day. Some side effects of Tyrvaya (varenicline) include sneezing, cough, and throat irritation.

    Summary for LFA-1 antagonist
    Prescription only

    Xiidra (lifitegrast) is an eye drop medication that treats dry eye in adults. It belongs to a drug class called LFA-1 antagonists. It's thought help lower inflammation and other symptoms of dry eye. Usually, you need to use Xiidra (lifitegrast) every day. You put 1 drop into each eye twice a day. Side effects include temporary eye irritation and unclear vision. At this time, Xiidra (lifitegrast) is available only as a brand medication. There's no generic version yet.

  • Indications of Tyrvaya vs. Xiidra

    Indications for
    •Dry eye
    Indications for
    •Dry eye

  • Pros and Cons of Tyrvaya vs. Xiidra

    Pros and Const for Cholinergic agonist
    Pros
    •Can relieve dry eyes in as quickly as 5 minutes
    •Can cause eyes to make 50% more tears after a month of treatment
    •Can be stored at room temperature
    Cons
    •Must be used twice a day and in each nostril
    •Brand name only
    •Commonly causes sneezing as a side effect
    Pros and Const for LFA-1 antagonist
    Pros
    •Works to help treat dry eye in the long run
    •Might be less likely to cause burning in the eyes than Restasis (cyclosporine)
    Cons
    •Won't give you instant relief and have to take for a couple weeks before it starts working
    •Not approved for people younger than 17 years old

  • Common Side Effects of Tyrvaya vs. Xiidra

    Common Side Effects for
    •Sneezing (82%)
    •Cough (16%)
    •Throat irritation (13%)
    •Nose irritation (8%)
    Common Side Effects for
    •Eye irritation (5-25%)
    •Strange taste in the mouth (5-25%)
    •Unclear vision (5-25%)

  • Warnings of Tyrvaya vs. Xiidra

    Common Side Effects for
    Common Side Effects for
    •Risk of contamination

  • Prices with our coupons for Tyrvaya vs. Xiidra

    Learn more about Tyrvaya
    Learn more about Xiidra

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