Tyrvaya
Tyrvaya (varenicline) is a cholinergic agonist. It's a nasal spray used to treat dry eye in adults. This medication is sprayed into each nostril, typically twice a day. Some side effects of Tyrvaya (varenicline) include sneezing, cough, and throat irritation.
What is Tyrvaya (varenicline)?
What is Tyrvaya (varenicline) used for?
How Tyrvaya (varenicline) works
Tyrvaya (varenicline) is a cholinergic agonist. The exact way it works to treat dry eye isn't well-understood. But it's thought to work by activating certain receptors in the body responsible for making tear film. So Tyrvaya (varenicline) soothes dry eyes by helping your body make more of its own natural tear film.
Drug facts
Side effects of Tyrvaya (varenicline)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sneezing (82%)
- Cough (16%)
- Throat irritation (13%)
- Nose irritation (8%)
The following Tyrvaya (varenicline) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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Pros and cons of Tyrvaya (varenicline)
Pharmacist tips for Tyrvaya (varenicline)
- Tyrvaya (varenicline) comes with two bottles. Each bottle should last about 15 days. Open the second bottle only after you have finished the first.
- Don't shake Tyrvaya (varenicline) since this can damage the medication. This spray is different from other nasal sprays.
- Store Tyrvaya (varenicline) at room temperature. Don't ever freeze it or this could damage the medication and make it not work as well. Make sure to throw away any open bottle after 30 days.
Read the instructions for use or watch this video to get familiar with using Tyrvaya (varenicline):
- Before using Tyrvaya (varenicline) spray for the first time, you'll need to prime (ready) your bottle. Do this by spraying 7 sprays into the air away from your face. This will help make sure you get the right dose.
- If you haven't used Tyrvaya (varenicline) for more than 5 days, you'll need to re-prime it by spraying one spray into the air away from your face before using it again.
- When you're ready for your dose, gently blow your nose first if needed then tilt your head back slightly and insert the tip of the Tyrvaya (varenicline) spray bottle just past the opening of your nostril. Don't put it in too deep since you don't want to spray the medication into your sinuses.
- Aim the tip of the Tyrvaya (varenicline) spray out towards your ear (on the same side of the nostril you're spraying into) and press your tongue to the roof of your mouth. Breathe gently as you press and release the applicator. The medication will be absorbed into the walls of your nose.
- Then repeat using Tyrvaya (varenicline) in the other nostril.
- Wipe the nasal applicator with a clean tissue each time after using it.
Common questions about Tyrvaya (varenicline)
No, Tyrvaya (varenicline) isn't a steroid; but rather, it belongs to a group of medications called cholinergic agonists. Typically, steroid nasal sprays are used to ease allergy symptoms, such as runny nose and congestion. But Tyrvaya (varenicline) is used to treat dry eye by triggering your eyes to make more tears.
Before using Tyrvaya (varenicline), make sure to prime your bottle by pressing and releasing the applicator 7 times. Once you're ready, hold the Tyrvaya (varenicline) nasal spray upright and place one finger on each side of the top and your thumb underneath. Tilt your head back slightly and insert the nasal applicator into one nostril. Point the tip towards the top of the ear on the same side as your nostril. But don't press the tip against the wall of your nose; make sure to leave a small gap. Put your tongue to the roof of your mouth, breathe gently, and press and release the applicator once. Repeat this in your other nostril. Never use Tyrvaya (varenicline) in your eyes since it's only meant to be used as a nasal spray.
Two different one-month studies looked at how well Tyrvaya (varenicline) worked to treat dry eyes. About half of people who used Tyrvaya (varenicline) noticed 50% more tear production at the end of treatment. But only about a-third of the people who used placebo (a spray with no medication in it) noted the same results. Tyrvaya (varenicline) might not work well for everyone. Let your ophthalmologist know if you don't see an improvement in your symptoms after about a month.
Tyrvaya (varenicline) works pretty fast, even as quickly as 5 minutes after the first dose. But this medication might take a bit longer to work for some people.
Each Tyrvaya (varenicline) nasal spray bottle contains 60 sprays, which should last you 15 days. Tyrvaya (varenicline) comes as a carton that contains two bottles, so you'll have enough sprays for a 30 day supply. But because you need to prime your Tyrvaya (varenicline) spray bottle when you first use it or anytime you stopped using it for 5 days or longer, each bottle might last less than 15 days.
There isn't enough information available to know if Tyrvaya (varenicline) is safe to take during pregnancy. If you're pregnant, discuss the risks and benefits of using Tyrvaya (varenicline) with your obstetrician. Also, ask them about other options to treat dry eyes.
If you happen for miss a dose of Tyrvaya (varenicline), just skip that dose and take your next dose at your usual time. Don't take extra doses to make up for missed doses of Tyrvaya (varenicline), because this could lead to side effects.
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Tyrvaya (varenicline) dosage
Carton| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 2 nasal spray bottles of 0.03mg | 1 carton | $0.00 | $0.00 |
| 1 nasal spray bottle of 0.03mg | 1 carton | $0.00 | $0.00 |
Typical dosage for Tyrvaya (varenicline)
Each spray contains 0.03 mg of varenicline.
- Adults: The typical dose is 1 spray in each nostril every 12 hours.
How much does Tyrvaya (varenicline) cost?
$0.00
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