Key takeaways
Xiidra (lifitegrast) and Lacrisert (hydroxypropyl cellulose) are both prescription medications used to treat dry eyes, but they work in different ways and have different forms. Xiidra is an eye drop that you apply twice daily, while Lacrisert is a small insert placed in the eye once a day. Xiidra works by blocking a protein that causes inflammation, which helps reduce redness and irritation over time. On the other hand, Lacrisert acts as a long-lasting artificial tear, thickening the tear film to keep your eyes moist. Xiidra can cause temporary eye irritation and blurry vision, but these side effects usually go away quickly. Lacrisert can also cause blurry vision and eye discomfort, and it can be tricky to place correctly at first. Xiidra and Lacrisert are only available as a brand name medication.
