Key takeaways
Acetaminophen (Tylenol) and naproxen (Naprosyn) are both used to relieve pain, but they work differently and have different uses. Acetaminophen is an over-the-counter analgesic that helps with mild pain and fever but doesn't reduce inflammation. It's available in many forms, like tablets and liquids, and is generally safe with few side effects, though it can cause liver damage if taken in high doses or with alcohol. On the other hand, Naprosyn is a prescription-only non-steroidal anti-inflammatory drug (NSAID) that treats pain and inflammation from conditions like arthritis and gout. It works by blocking proteins that cause inflammation and pain. Naprosyn can cause stomach issues, heart problems, and kidney damage, especially if used long-term or in higher doses. Compared to acetaminophen, Naprosyn is more effective for inflammatory conditions. Of note, naproxen is also available over-the-counter (Aleve).
