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Tretinoin vs. Ascorbic acid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Retin-A

(tretinoin)

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Vitamin C

(ascorbic acid)

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Summary for Tretinoin

Prescription only

Retin-A (tretinoin) is a retinoid medication that's used to treat acne in adults and children 12 years and older. It's available as a cream or a gel that's applied onto the skin once a day. Side effects include skin irritation, redness, and peeling. Your acne might get worse at the beginning of treatment, but it should get better as you continue using the medication. You must have a prescription for Retin-A (tretinoin) from your primary care provider or dermatologist; this medication isn't available over the counter.

Indications for Tretinoin

  • Acne

Pros and Cons for Tretinoin

Pros

  • Easy to apply onto your skin
  • Only need to apply once nightly
  • Available in a lower-cost generic form

Cons

  • Makes your skin more sensitive to sunlight, which can lead to sunburns
  • Can cause your skin color to temporarily become lighter or darker
  • Might worsen your acne during the first few weeks of treatment

Common Side Effects for Tretinoin

  • Skin peeling or discomfort
  • Warm feeling or stinging after applying
  • Skin redness
  • Sensitivity to sunlight (sunburns)
  • Worsening of acne in the first few weeks of treatment

Warnings for Tretinoin

  • Sunburns
  • Skin irritation in extreme weather
  • Skin reactions

Summary for Ascorbic acid

Over-the-counter

Vitamin C (ascorbic acid) is a dietary supplement that's available over the counter. It's typically used for people who aren't getting enough of the vitamin from the foods in their diet. The supplement commonly comes as tablets, chewable tablets, gummies, and oral liquid. While vitamin C (ascorbic acid) is important for several bodily functions, some of its suggested benefits (e.g., preventing colds) aren't clear. Side effects typically aren't common when you take vitamin C (ascorbic acid) supplements at recommended doses, but they're more likely to happen if you take too much.

Indications for Ascorbic acid

  • Dietary supplement

Pros and Cons for Ascorbic acid

Pros

  • Typically taken once daily
  • Available over the counter and as a lower-cost generic
  • Available as chewable tablets or gummies that might be a good option for people who have trouble swallowing pills whole
  • Some chewable tablets and gummies are fruit-flavored for better taste.

Cons

Common Side Effects for Ascorbic acid

See Risks and Warnings.

Warnings for Ascorbic acid

  • Toxicity from too much vitamin C

Prices with our coupons for Tretinoin vs. Ascorbic acid

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Tretinoin1 tube / 45g of 0.025%
$48.29$94.25
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Vitamin C30 tablets / 500mg
$8.06$10.21
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