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Risperdal vs. Abilify

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Risperidone (Risperdal) and aripiprazole (Abilify) are both atypical antipsychotics used to treat mental health conditions like schizophrenia and bipolar disorder. Risperidone is also used for irritability in children with autism, while aripiprazole is used for Tourette syndrome and as an add-on treatment for depression. Risperidone is available in various forms, including tablets, dissolvable tablets, and oral solutions, and is typically taken once or twice daily. In contrast, aripiprazole is usually taken once daily and comes in tablets, oral solutions, and orally disintegrating tablets. Common side effects of risperidone include sleepiness, movement problems, and weight gain, whereas aripiprazole often causes headaches, movement problems, and sleep issues. Aripiprazole is less likely to cause weight gain compared to risperidone. Both medications can raise blood sugar and cholesterol levels, but aripiprazole has a lower risk of these side effects.

Risperidone

(Risperdal)

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Aripiprazole

(Abilify)

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Summary for Risperdal

Prescription only

Risperidone (Risperdal) is an atypical antipsychotic that's used to improve mood, thoughts, and behaviors in people with schizophrenia, bipolar disorder, and autism. It's taken by mouth, typically once or twice daily. Common side effects of risperidone (Risperdal) include sleepiness, movement problems, and weight gain. Risperidone (Risperdal) can interact with some medications, such as certain antidepressants or blood pressure medications. Taking these medications together can make certain side effects worse.

Indications for Risperdal

  • Schizophrenia - people ages 13 years and older
  • Manic or mixed episodes associated with bipolar I disorder - people ages 10 years and older
  • Irritability associated with autism - children ages 5 to 17 years old

Pros and Cons for Risperdal

Pros

  • Taken by mouth
  • Available as a pill, dissolving tablet, and liquid
  • Can be used in both adults and children
  • Available as a lower-cost generic

Cons

  • Higher risk of sexual problems, compared to other atypical antipsychotics
  • Can cause weight gain
  • Can cause changes to sleep or movement problems
  • Shouldn't be mixed with alcohol

Common Side Effects for Risperdal

Adults:

  • Muscle stiffness, muscle tightening, difficulty with movement (25%)
  • Extreme sleepiness (11%)
  • Restlessness, trouble remaining still (9%)
  • Tremor (6%)
  • Dizziness (6%)
  • Nausea (5%)
  • Repetitive movements, abnormal postures (5%)

Children:

  • Extreme sleepiness (up to 56%)
  • Dizziness (up to 16%)
  • Nausea or vomiting (up to 16%)
  • Stomach pain (up to 16%)
  • Muscle stiffness, muscle tightening, difficulty with movement (up to 12%)
  • Heartburn (up to 10%)
  • Sore throat (up to 10%)

Warnings for Risperdal

  • Higher risk of death in older adults with dementia-related psychosis
  • Neuroleptic malignant syndrome
  • Difficulty controlling muscle movements (tardive dyskinesia)
  • Weight gain, higher blood sugar, and higher cholesterol levels
  • High prolactin levels
  • Changes in blood pressure and higher risk of falls
  • Risk of infection (from low white blood cell count)
  • Difficulty concentrating and extreme sleepiness
  • Seizures
  • Prolonged and painful erection
  • Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

Summary for Abilify

Prescription only

Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

  • Can make you feel restless
  • Risk of movement problems that can be permanent
  • Can raise blood sugar and cholesterol
  • Can take several weeks to see the full effects

Common Side Effects for Abilify

  • Headache (27%)
  • Agitation (19%)
  • Trouble sleeping (18%)
  • Anxiety (17%)
  • Nausea (15%)
  • Vomiting (11%)
  • Constipation (11%)
  • Dizziness (10%)
  • Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.

Warnings for Abilify

  • Higher risk of death in older adults with dementia-related psychosis
  • Neuroleptic malignant syndrome
  • High blood sugar, high cholesterol, and weight gain
  • Difficulty controlling movements
  • Changes in blood pressure and higher risk of falls
  • Risk of infection (from low white blood cell count)
  • Difficulty concentrating and extreme sleepiness
  • Seizures
  • Impulse-control problems

Prices with our coupons for Risperdal vs. Abilify

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Risperidone30 tablets / 1mg
$9.00$9.00
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Aripiprazole30 tablets / 5mg
$12.66$439.57
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