Key takeaways
Tretinoin (Renova) and benzoyl peroxide are both topical medications used for skin conditions, but they belong to different drug classes and have distinct uses. Tretinoin is a topical retinoid primarily used to lessen the appearance of fine facial wrinkles, while benzoyl peroxide is used to treat acne and woprks by preventing acne-causing bacteria from growing and multiplying on your face. Tretinoin is a prescription medication and is applied once daily in the evening, whereas benzoyl peroxide can be purchased over-the-counter and is applied 1 to 3 times daily, depending on the form and your provider's instructions. Tretinoin is not available as a generic, while benzoyl peroxide is available in various forms and strengths, including a lower-cost generic. Common side effects of tretinoin include skin irritation, peeling, and redness, while benzoyl peroxide can cause redness, burning, and itching, and may bleach hair and clothing. Both medications can increase your skin's sensitivity to sunlight, so it's important to use sunscreen and protective clothing when using either one.
