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Qualaquin vs. Plaquenil

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Quinine (Qualaquin) and hydroxychloroquine (Plaquenil) are both antimalarial medications, but they have different uses and side effects. Quinine is specifically used to treat malaria in people aged 16 and older and must be taken every 8 hours for 7 days. It has many side effects, including nausea, stomach pain, and serious risks like abnormal heart rhythms and bleeding problems. Hydroxychloroquine, on the other hand, is used to prevent and treat malaria in both adults and children, and it is also used to treat rheumatoid arthritis and lupus in adults. It is typically taken once or twice a day with food or milk. Common side effects include nausea, vomiting, and diarrhea, but it can also cause serious issues like heart rhythm problems and eye damage. Both medications are available as a lower-cost generic, making them more affordable. Both medications require a prescription and have significant interactions with other medications, so it's important to discuss all your medications with your healthcare provider.

Quinine

(Qualaquin)

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Hydroxychloroquine

(Plaquenil)

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Summary for Qualaquin

Prescription only

Quinine (Qualaquin) is used to treat malaria in people ages 16 years and older. It's not used for preventing malaria. It's available as a capsule taken every 8 hours. Side effects of quinine (Qualaquin) include nausea, stomach pain, and vomiting. Taking it with food can ease some stomach-related side effects. It's typically not a first-choice option because it has a lot of side effects, drug interactions, and needs to be taken in combination with either doxycycline (Vibramycin, Doryx) or certain other antimalarial medications.

Indications for Qualaquin

Pros and Cons for Qualaquin

Pros

  • Only need to take for a week to treat malaria
  • Taken by mouth
  • Available as a lower-cost generic

Cons

  • Taken every 8 hours
  • Only available as a capsule
  • Interacts with a lot of medications, including certain antiseizure medications and antibiotics

Common Side Effects for Qualaquin

  • Headache
  • Sweating
  • Ringing in the ears
  • Hearing loss
  • Dizziness
  • Blurry vision
  • Changes in how you see color

Warnings for Qualaquin

  • Not for leg cramps
  • Low platelet counts (thrombocytopenia)
  • Hemolytic anemia (low red blood cells)
  • Life-threatening abnormal heart rhythm
  • Low blood sugar
  • Severe skin and allergic reactions

Summary for Plaquenil

Prescription only

Hydroxychloroquine (Plaquenil) is a non-biologic disease-modifying anti-rheumatic drug (DMARD) used to treat rheumatoid arthritis (RA) and lupus in adults. It's also an antimalarial medication used to prevent and treat malaria in adults and children. Hydroxychloroquine (Plaquenil) is taken by mouth, typically once or twice per day. Some of the more common side effects of this medication include nausea, vomiting, and diarrhea.

Indications for Plaquenil

Pros and Cons for Plaquenil

Pros

Cons

  • Need to take with food or milk
  • Interacts with commonly prescribed medications, such as certain blood sugar medications or antibiotics
  • Can't be used in children for lupus

Common Side Effects for Plaquenil

Warnings for Plaquenil

  • Serious heart rhythm problems
  • Build-up of phospholipids (a type of fat)
  • Eye damage
  • Severe skin and allergic reactions
  • Lower blood cell counts
  • Hemolytic anemia (low red blood cells)
  • Suicidal thoughts
  • Lower blood sugar levels
  • Worsening of certain medical conditions

Prices with our coupons for Qualaquin vs. Plaquenil

Price Card Drug Icon
Quinine30 capsules / 324mg
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Hydroxychloroquine60 tablets / 200mg
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