Compare
Prolia vs. Jubbonti

Prolia (denosumab) is an injection that's used to treat osteoporosis in adults at high risk of fracture. It's also for those at high risk of fractures from certain cancer medications. It works as a monoclonal antibody called a RANKL inhibitor to strengthen your bones. Prolia (denosumab) is a convenient option because you only need an injection every 6 months. It's injected under the skin by a healthcare professional at a medical office. Side effects include back and muscle pain. It also has a risk of causing dangerously low calcium levels.

• Osteoporosis in women who've gone through menopause and at high risk of fracture
• Osteoporosis in men at high risk of fracture
• Osteoporosis caused by steroid medications in people at high risk of fracture
• Bone loss in men at high risk of fracture taking certain medications for prostate cancer
• Bone loss in women at high risk of fracture taking certain breast cancer medications

• Back pain (35%)
• Pain in the arm or leg (12%)
• Muscle, bone, or joint pain (up to 8%)
• High cholesterol levels (7%)
• Pain or discomfort while urinating and other symptoms of a bladder infection (6%)
• Sensation that the room is spinning (5%)
• Swelling in the hands or feet (5%)
• Upper respiratory tract infection (5%)

• Dangerously low calcium levels
• Risk of fractures in the thigh bone
• Risk of spine fractures after stopping Prolia (denosumab)
• Risk of serious infections
• Risk of problems in the jawbone
• Serious allergic reactions and skin reactions
• Severe bone, muscle, or joint pain
• Don't take with Xgeva (denosumab)

Jubbonti (denosumab or denosumab-bbdz) is a RANKL inhibitor used to treat osteoporosis and certain types of bone loss caused by treatment. It’s approved for adults at high risk of fractures, including after menopause, during long‑term steroid use, and during some prostate or breast cancer treatments. The medication is injected under the skin by a healthcare professional once every 6 months. Common side effects can include back pain, joint or muscle pain, and higher cholesterol.

Jubbonti (denosumab) is an interchangeable biosimilar to Prolia (denosumab).

• Osteoporosis in women who've gone through menopause and at high risk of fracture
• Osteoporosis in men at high risk of fracture
• Osteoporosis caused by steroid medications in people at high risk of fracture
• Bone loss in men at high risk of fracture taking certain medications for prostate cancer
• Bone loss in women at high risk of fracture taking certain breast cancer medications

Postmenopausal women with osteoporosis:

• Back pain (35%)
• Pain in the arms or legs (12%)
• Muscle pain (8%)
• High cholesterol levels (7%)
• Bladder inflammation (6%)
• Vertigo (5%)
• Swelling in the hands or feet (5%)
• Upper respiratory tract infection (5%)
• Nerve pain (5%)

Men with osteoporosis:

• Back pain (8%)
• Joint pain (7%)
• Common cold symptoms (7%)

Osteoporosis caused by corticosteroids:

• Back pain (5%)
• High blood pressure (4%)
• Bronchitis (4%)
• Headache (4%)

Bone loss from cancer treatments:

• Joint pain (14%)
• Back pain (12%)

• Dangerously low calcium levels
• Allergic reactions
• Jawbone damage
• Thigh bone fractures
• Multiple spine fractures after stopping treatment
• Serious infections
• Severe skin reactions
• Severe bone, muscle, or joint pain