Compare
Prolia vs. Evenity

Prolia (denosumab) is an injection that's used to treat osteoporosis in adults at high risk of fracture. It's also for those at high risk of fractures from certain cancer medications. It works as a monoclonal antibody called a RANKL inhibitor to strengthen your bones. Prolia (denosumab) is a convenient option because you only need an injection every 6 months. It's injected under the skin by a healthcare professional at a medical office. Side effects include back and muscle pain. It also has a risk of causing dangerously low calcium levels.

• Osteoporosis in women who've gone through menopause and at high risk of fracture
• Osteoporosis in men at high risk of fracture
• Osteoporosis caused by steroid medications in people at high risk of fracture
• Bone loss in men at high risk of fracture taking certain medications for prostate cancer
• Bone loss in women at high risk of fracture taking certain breast cancer medications

• Back pain (35%)
• Pain in the arm or leg (12%)
• Muscle, bone, or joint pain (up to 8%)
• High cholesterol levels (7%)
• Pain or discomfort while urinating and other symptoms of a bladder infection (6%)
• Sensation that the room is spinning (5%)
• Swelling in the hands or feet (5%)
• Upper respiratory tract infection (5%)

• Dangerously low calcium levels
• Risk of fractures in the thigh bone
• Risk of spine fractures after stopping Prolia (denosumab)
• Risk of serious infections
• Risk of problems in the jawbone
• Serious allergic reactions and skin reactions
• Severe bone, muscle, or joint pain
• Don't take with Xgeva (denosumab)

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh