Key takeaways
Famotidine (Pepcid AC, Zantac 360) and calcium carbonate/magnesium hydroxide (Rolaids) are both used to treat heartburn, but they work differently and have different uses. Famotidine is a histamine-2 (H2) antagonist that reduces the amount of acid your stomach makes, and it can be used for conditions like stomach ulcers and GERD. It is available both over-the-counter and by prescription, and it usually needs to be taken twice a day. Common side effects include headache, dizziness, and constipation. On the other hand, Rolaids is an antacid that works by neutralizing stomach acid quickly to relieve heartburn and indigestion. It is available over-the-counter and is taken as needed, but it doesn't last as long as famotidine. Rolaids can interact with other medications and may cause high blood calcium levels, especially if you have kidney problems. While famotidine is generally well-tolerated, Rolaids provides faster relief but is not meant for long-term use.
