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Paxil vs. Xanax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Paroxetine (Paxil) and alprazolam (Xanax) are both used to treat anxiety, but they belong to different medication classes and work differently. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels to help regulate mood. It is available in both brand and generic forms and can treat various conditions like depression, panic disorder, and social anxiety disorder. Alprazolam, on the other hand, is a benzodiazepine that provides quick relief by affecting chemicals in the brain related to anxiety. It is typically used for short-term treatment of anxiety and panic attacks. Paroxetine is taken once daily, while alprazolam is usually taken up to three times a day. Paroxetine can take several weeks to show full benefits, whereas alprazolam starts working within 30 minutes. Both medications can cause withdrawal symptoms if stopped abruptly, but only alprazolam is a controlled substance due to its potential for addiction and misuse.

Paroxetine

(Paxil)

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Alprazolam

(Xanax)

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Summary for Paxil

Prescription only

Paroxetine (also known by it's brand name Paxil) is a selective serotonin reuptake inhibitor (SSRI), used for different types of anxiety problems and depression. It's available as a brand name and generic version, and it comes as an immediate-release tablet, an oral suspension, and an extended-release tablet. Possible side effects include nausea, sexual side effects, and weight gain. It can also cause withdrawal symptoms (e.g., headache, trouble sleeping, anxiety) if you suddenly stop taking it.

Indications for Paxil

Pros and Cons for Paxil

Pros

  • Only needs to be taken once daily
  • Available as a tablet and oral liquid
  • Can be taken with or without food
  • Can be used for many different mental health conditions
  • Can be helpful for people who have both anxiety and depression

Cons

Common Side Effects for Paxil

  • Abnormal ejaculation (up to 28%)
  • Nausea (up to 25%)
  • Weakness (up to 22%)
  • Sleepiness or trouble sleeping (up to 24%)
  • Dry mouth (up to 18%)
  • Constipation (up to 16%)
  • Sweating (up to 14%)
  • Dizziness (up to 14%)
  • Diarrhea (up to 12%)
  • Low libido (up to 12%)
  • Shakiness (up to 11%)

Warnings for Paxil

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Risk of harm to unborn babies
  • Sexual problems
  • Withdrawal
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Low blood sodium levels
  • Seizures
  • Risk of abnormal heart rhythm from interactions

Summary for Xanax

Prescription only

Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.

Indications for Xanax

Pros and Cons for Xanax

Pros

  • Taken by mouth
  • Can start to work in 30 minutes
  • Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Xanax

Generalized anxiety disorder:

  • Drowsiness (41%)
  • Lightheadedness (21%)
  • Dry mouth (15%)

Panic disorder:

  • Drowsiness (77%)
  • Fatigue (49%)
  • Poor coordination (40%)
  • Memory issues (33%)
  • Irritability (33%)
  • Appetite changes (28-33%)
  • Thinking problems (29%)
  • Constipation (26%)

Side effects listed are for the immediate-release forms. Side effects for extended-release form might differ.

Warnings for Xanax

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies
  • Interactions with other medications
  • Use with caution in people with depression

Prices with our coupons for Paxil vs. Xanax

Price Card Drug Icon
Paroxetine90 tablets / 20mg
$10.00$10.00
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Alprazolam30 tablets / 0.5mg
$10.40$14.84
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