Key takeaways
Paroxetine (Paxil) and fluoxetine (Prozac) are both selective serotonin reuptake inhibitors (SSRIs) used to treat mental health conditions, but they have some differences. Paroxetine is available in both immediate-release and extended-release forms and is used for a variety of conditions including depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Fluoxetine, on the other hand, is available in immediate-release and delayed-release forms and is used for conditions like depression, OCD, bulimia, panic disorder, and treatment-resistant depression. Paroxetine is more likely to cause weight gain and sexual side effects compared to fluoxetine, which is less likely to cause weight gain but can cause more sleep-related issues. Both medications can cause withdrawal symptoms if stopped suddenly and can interact with other medications, especially those affecting serotonin levels. Paroxetine is taken once daily, while fluoxetine can be taken once daily or once weekly, depending on the form.
