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Olopatadine vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Olopatadine (Pataday) and cetirizine (Zyrtec) are both antihistamines used to treat allergy symptoms, but they have some key differences. Olopatadine is an eye drop used to relieve eye itching and redness caused by allergies, while cetirizine is taken orally to treat a broader range of allergy symptoms, including runny nose and watery eyes. Olopatadine is available over-the-counter and is used once or twice daily, depending on the strength. Cetirizine is also available over-the-counter and comes as tablets, chewable tablets, or liquid solutions. Cetirizine is typically taken once a day. Olopatadine can cause blurry vision and should not be used with contact lenses immediately after applying the drops, whereas cetirizine can cause drowsiness and is not recommended to be taken with alcohol. Additionally, cetirizine is safe for use during pregnancy, while you should consult your provider before using olopatadine if you're pregnant.

Olopatadine

(Pataday)

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Cetirizine

(Zyrtec)

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Summary for Olopatadine

Over-the-counter

Olopatadine (Pataday) is an over-the-counter (OTC) allergy eye drop for adults and children 2 years and up. It works as an antihistamine to help relieve itchy and red eyes from allergies. There are 3 types of olopatadine eye drops (Pataday). There's a lower-strength version that's used twice a day. Regular-strength and extra-strength versions that are used once a day are also available. Some side effects include blurry vision and dry eye.

Indications for Olopatadine

Pros and Cons for Olopatadine

Pros

  • Works within minutes to help relieve itchy and red eyes from allergies
  • Safe for children over 2 years old
  • Available over the counter

Cons

  • Not for irritation caused by eye infections, contact lenses, or dry eye
  • Contains preservatives, which can cause eye irritation
  • Must take out contact lenses first before using

Common Side Effects for Olopatadine

  • Blurry vision
  • Burning or stinging in the eye
  • Feeling like something is in the eye
  • Common cold symptoms
  • Sore throat

Warnings for Olopatadine

  • For use in the eyes only
  • Remove contact lenses before use

Summary for Zyrtec

Prescription or over-the-counter

Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

Indications for Zyrtec

  • Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
  • Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only

Pros and Cons for Zyrtec

Pros

  • First-choice option for relieving allergy symptoms
  • Taken once per day
  • Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
  • Safe to take while pregnant

Cons

  • Can cause you to feel sleepy
  • Higher risk of side effects in people with liver or kidney problems
  • Pills can't be used in children younger than 6 years.

Common Side Effects for Zyrtec

People 12 years of age and older:

  • Sleepiness (14%)
  • Tiredness (6%)
  • Dry mouth (5%)

Children age 6 to under 12 years:

  • Headache (11-14%)
  • Sore throat (3-6%)
  • Stomach pain (4-6%)
  • Cough (3-4%)
  • Sleepiness (2-4%)

Warnings for Zyrtec

  • Sleepiness
  • Accidentally taking too much medication

Prices with our coupons for Olopatadine vs. Zyrtec

Price Card Drug Icon
Olopatadine1 eye dropper / 5ml of 0.1%
$10.91$17.16
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Cetirizine90 tablets / 24 hour of 10mg
$9.11$14.28
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