Key takeaways
Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) are both single-tablet regimens used to treat HIV. Odefsey contains a newer form of tenofovir, which is safer for your kidneys and bones compared to the tenofovir in Atripla. Odefsey must be taken with a meal, while Atripla should be taken on an empty stomach, preferably at bedtime to avoid side effects like dizziness and headache. Atripla is available as a generic, making it more affordable, but it is no longer a first-choice treatment due to its side effects. Both medications can cause kidney and bone problems, but Odefsey is considered safer in these aspects. Additionally, Atripla has more common side effects like mood changes and abnormal dreams, whereas Odefsey has fewer side effects overall.
