Key takeaways
Nasacort (triamcinolone acetonide) and Nyquil Cold and Flu (acetaminophen/dextromethorphan/doxylamine) are both over-the-counter medications, but they serve different purposes and have different active ingredients. Nasacort is a corticosteroid nasal spray used to relieve hay fever and allergy symptoms like sneezing, runny nose, and nasal congestion. It works by reducing inflammation in your nose and is typically used once daily. On the other hand, Nyquil Cold and Flu is a combination of a pain reliever, cough suppressant, and antihistamine, used to treat cold and flu symptoms such as cough, sore throat, fever, and runny nose. Nyquil is taken orally and can make you feel sleepy, so it's often used at night. Nasacort isn't likely to make you tired. While Nasacort is generally safe for long-term use under guidance, Nyquil is meant for short-term use and should not be taken with other medications containing acetaminophen due to the risk of liver damage.
