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Lidoderm vs. Cortisone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lidoderm (lidocaine 5% patch) and cortisone are both prescription medications that can hep with pain, but they belong to different drug classes and treat different conditions. Lidoderm is a local anesthetic specifically FDA-approved for treating nerve pain from shingles, known as postherpetic neuralgia. It works by numbing the nerves in the skin. Cortisone is a corticosteroid used to treat conditions involving an overactive immune system, such as rheumatoid arthritis and lupus. It help reduce swelling to help with pain and movement problems associated with these conditions. Lidoderm is applied as a 5% patch once a day for up to 12 hours, while cortisone is an oral tablet, and the dosing varies widely based on the condition being treated. Both medications are available as a lower-cost generic. Common side effects of Lidoderm include skin irritation and whereas cortisone can cause fluid retention and insomnia, and may lead to an increased risk of infections and bone weakening with long-term use.

Lidocaine 5% patch

(Lidoderm)

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Cortisone

 

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Summary for Lidoderm

Prescription only

Lidocaine 5% patch (Lidoderm) is a prescription medication used to relieve nerve pain caused by a shingles infection, also called postherpetic neuralgia (PHN). It's a local anesthetic that works by numbing your nerves to help reduce pain. You apply the patch directly to the painful area of your skin once a day, and it can be worn for up to 12 hours in a 24-hour period. Common side effects include temporary skin irritation, redness, and a mild burning sensation where the patch is applied.

Indications for Lidoderm

Pros and Cons for Lidoderm

Pros

  • Works directly on the skin
  • Generally well-tolerated with few side effects
  • Can cut patches to fit the area of pain

Cons

  • Commonly causes skin irritation
  • Must avoid contact with water wearing the patch
  • Might interact with many medications

Common Side Effects for Lidoderm

  • Blisters
  • Bruising
  • Burning sensation
  • Changes in skin color
  • Rash or redness
  • Swelling
  • Peeling or flaking skin
  • Itching
  • Small bumps or spots
  • Tiny red or purple dots under the skin
  • Tingling or numbness in the area

Warnings for Lidoderm

  • Blood problem (methemoglobinemia)
  • Absorbing too much medication
  • Accidental poisoning in children or pets

Summary for Cortisone

Prescription only

Cortisone is a short-acting steroid medication used to treat different conditions that involve an overactive immune system. It's taken by mouth, but your dose can differ depending on condition you taking cortisone for. Short-term side effects of cortisone include changes in appetite, mood swings, and trouble sleeping. If you take this medication for a long time, you might experience weight gain or weakening of your bones.

Indications for Cortisone

Cortisone is used for many different medical conditions, including:

Pros and Cons for Cortisone

Pros

  • Available as a lower-cost, generic medication
  • Works well to treat many different conditions involving the immune system
  • Less potent compared to other steroids, which might lead to fewer side effects

Cons

  • Long-term use might weaken your bones and cause high blood sugar
  • Can slow down growth in children
  • Stopping suddenly can lead to withdrawal symptoms if you've been taking it for a long time

Common Side Effects for Cortisone

  • Swelling
  • Muscle weakness
  • Stomach pain
  • Bloating
  • Increased appetite
  • Trouble sleeping
  • Weight gain
  • Dizziness
  • Nausea

Warnings for Cortisone

  • New or worsened infection
  • Mood and behavior changes
  • Reduced adrenal gland health
  • Changes in heart and kidney function
  • Stomach problems
  • Eye problems with long-term use
  • Bone problems with long-term use
  • High blood sugar

Prices with our coupons for Lidoderm vs. Cortisone

Price Card Drug Icon
Lidocaine30 patches / 5%
$60.46$288.86
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Cortisone30 tablets / 25mg
$39.45$532.99
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