Levemir vs. Novolog for Diabetes Type 2 and Diabetes Type 1: Important Differences and Potential Risks.

Key takeaways

Levemir (insulin detemir) and NovoLog (insulin aspart) are both insulins used to manage diabetes, but they have different purposes and characteristics. Levemir is a long-acting insulin that helps control blood sugar levels for up to 24 hours and is typically injected once or twice daily. In contrast, NovoLog is a rapid-acting insulin that starts working within 15 minutes and is usually taken right before meals to manage blood sugar spikes from eating. Levemir is available in vials and FlexPens, while NovoLog comes in vials, prefilled pens, and can also be used in insulin pumps. Levemir is often used in combination with rapid-acting insulins like NovoLog for comprehensive blood sugar management. Both insulins can cause low blood sugar, but NovoLog's rapid action requires careful timing with meals to avoid low blood sugar. Levemir has a lower risk of weight gain compared to some other insulins, while NovoLog can lead to weight gain over time.

Levemir

(insulin detemir)

Get free coupons

NovoLog

(insulin aspart)

Get free coupons

Summary for Levemir

Prescription only

Levemir (insulin detemir) is a long-acting insulin that helps control high blood sugar levels in children and adults. It's injected under the skin, typically once or twice daily. Like all insulins, Levemir (insulin detemir) can raise your risk for low blood sugar, so make sure to keep fast-acting sugars with you in case your blood sugar level drops too low. This medication comes in vials. But it's also available as a Flexpen for people who have trouble drawing up insulin from the vial.

Indications for Levemir

Pros and Cons for Levemir

Pros

Lower risk of weight gain compared to some other types of insulin
Doses can be adjusted to meet your body's needs
Insulin pens available for people who've trouble using insulin vials
Provides blood sugar control for up to 24 hours

Cons

Must be injected
Might need to inject it twice daily
Can cause low blood sugar
No generic option available

Common Side Effects for Levemir

Shakiness, hunger, and other symptoms of low blood sugar (up to 93%, depending on what other blood sugar medications you're taking)
Common cold involving the nose, throat, and lungs (up to 27%)
Headache (up to 23%)
Pain or irritation of the throat (10%)
Back pain (8%)
Fever, chills, and other flu-like symptoms (up to 8%)
Stomach pain (6%)

Please note: These side effects were reported by people who took Levemir (insulin detemir) for type 1 diabetes. Your risk for side effects might be different if you have type 2 diabetes.

Warnings for Levemir

Infections
Low blood sugar
Severe allergic reactions
Low blood potassium levels
Swelling from fluids and risk of heart failure

Summary for Novolog

Prescription only

NovoLog (insulin aspart) is a fast-acting insulin for adults and children with diabetes. It lowers your blood sugar levels by moving the sugar into your body so it can be used for energy. NovoLog (insulin aspart) is available as vials and ready-to-use prefilled pens. It's typically injected under the skin at mealtimes, but it can also be given as an infusion into the veins by a healthcare provider for people in the hospital. Side effects include headache and low blood sugar (hypoglycemia).

Indications for Novolog

Type 1 diabetes in adults and children
Type 2 diabetes in adults

Pros and Cons for Novolog

Pros

Starts to work within 10 minutes to lower blood sugar levels
Dose can be easily adjusted to make treatment tailored to your specific needs
Can use if you have liver or kidney problems
Available as a prefilled pen for easier and convenient use

Cons

Given multiple times per day (before each meal)
Must give as an injection
Might be hard for some people to inject properly
Risk of low blood sugar and weight gain

Common Side Effects for Novolog

Type 1 diabetes:

Severely low blood sugar (17%)
Headache (12%)
Accidental injury (11%)
Nausea (7%)
Diarrhea (5%)

Type 2 diabetes:

Muscles slow to react (11%)
Severely low blood sugar (10%)
Fungal nail infection (10%)
Impairment of your senses (9%)
Urinary tract infection (8%)
Sinus infection (5%)
Chest pain (5%)
Stomach pain (5%)
Headache (5%)
Skin problems (5%)

Warnings for Novolog

Spread of infections from sharing injection supplies
Low blood sugar (hypoglycemia)
Low blood potassium levels
Swelling from fluid buildup and risk of heart failure when taken with certain blood sugar medications
Dangerously high blood sugar levels or buildup of ketones (for people who use insulin pump)