Key takeaways
Levetiracetam (Keppra) and divalproex (Depakote) are both antiepileptic medications used to treat seizures, but they have some key differences. Levetiracetam is available in both immediate-release and extended-release forms and is taken either once or twice daily, depending on the formulation. It is also used as an add-on treatment for myoclonic and generalized tonic-clonic seizures. Divalproex, on the other hand, comes in delayed-release and extended-release tablets, as well as sprinkle capsules, and is taken once or twice daily. Besides treating seizures, divalproex is also used for bipolar disorder and migraine prevention. Levetiracetam does not interact with food or other medications, while divalproex has many interactions, including with phenytoin and aspirin. Levetiracetam is considered safer during pregnancy compared to divalproex, which can cause serious birth defects, but levetiracetam still requires careful monitoring if used during pregnancy. Both medications can cause sleepiness and mood changes, but divalproex requires regular blood tests to monitor liver health and ammonia levels.
