Kenalog vs. Zilretta for Osteoarthritis: Important Differences and Potential Risks.

Triamcinolone injection

(Kenalog)

Zilretta

(triamcinolone)

Summary for Kenalog

Prescription only

Triamcinolone injection (Kenalog) is a steroid injection that helps reduce inflammation in adults and children. The medication is used to treat many conditions, including allergies, skin conditions, multiple sclerosis, arthritis, and gout attacks. It's typically given as a shot into the muscle (intramuscular) or directly into the affected joint (intra-articular). Side effects are similar to other steroid medications and can include trouble sleeping, mood changes, and injection side reactions.

Indications for Kenalog

This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:

Allergies or allergic reactions
Skin conditions
Conditions affecting certain hormones (e.g., low adrenal hormones)
Gut conditions (e.g., ulcerative colitis)
Conditions related to blood cells
Certain cancers (e.g., leukemia)
Nervous system conditions (e.g., multiple sclerosis)
Eye conditions
Kidney conditions
Lung conditions
Joint conditions (e.g., rheumatoid arthritis)
Lupus

Pros and Cons for Kenalog

Pros

Available in multiple strengths
Can be injected directly into the joints to reduce inflammation
A dose can last for several weeks
Safe for children and adults

Cons

Not safe during pregnancy or breastfeeding
Can raise your risk for infections
Causes side effects like headache, mood swings, and weight gain
Has a risk for bone loss or fractures

Common Side Effects for Kenalog

Injection site reactions
Swelling
High blood pressure
High blood sugar
Muscle weakness
Stomach pain
Trouble sleeping
Changes in your mood
Headache
Acne
Weight gain

Warnings for Kenalog

Serious nervous system problems
Severe allergic reactions
Heart and kidney problems
Hormone effects
Greater risk of infections
Eye problems
Stomach problems
Bone problems
Changes in mood and behavior
Cancer

Summary for Zilretta

Prescription only

Zilretta (triamcinolone) is a steroid injection used to treat knee pain from osteoarthritis in adults. It works by reducing inflammation in the joint, helping to relieve pain and stiffness. The typical dose is 32 mg injected directly into the knee (intra-articular) by a healthcare professional. Some potential side effects include joint swelling, cough, and bruising where the medication is injected.

Indications for Zilretta

Pain from osteoarthritis of the knee

Pros and Cons for Zilretta

Pros

Injected directly into the affected knee joint
Single injection per treatment
Lasts up to 3 months or longer

Cons

Must be given by a trained healthcare professional
Unknown if safe during pregnancy or breastfeeding
Side effects include joint swelling and bruising at the injection site

Common Side Effects for Zilretta

Joint swelling (3%)
Bruising at the injection site (2%)
Sinus infection (2%)
Cough (2%)

Warnings for Zilretta

Serious nervous system problems
Severe allergic reactions
Greater risk of infections
Hormone effects
Heart and kidney problems
Eye problems
Stomach problems
Bone problems
Changes in mood and behavior

Prices with our coupons for Kenalog vs. Zilretta

Triamcinolone1 vial / 1ml of 40mg/ml

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Zilretta1 kit / 32mg vial of 5ml

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Kenalog vs. Zilretta

Triamcinolone injection

Zilretta

Summary for Kenalog

Indications for Kenalog

Pros and Cons for Kenalog

Pros

Cons

Common Side Effects for Kenalog

Warnings for Kenalog

Summary for Zilretta

Indications for Zilretta

Pros and Cons for Zilretta

Pros

Cons

Common Side Effects for Zilretta

Warnings for Zilretta

Prices with our coupons for Kenalog vs. Zilretta

Compare other Osteoarthritis drugs

Browse medications by letter

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Triamcinolone injection

Zilretta

Summary for Kenalog

Indications for Kenalog

Pros and Cons for Kenalog

Pros

Cons

Common Side Effects for Kenalog

Warnings for Kenalog

Summary for Zilretta

Indications for Zilretta

Pros and Cons for Zilretta

Pros

Cons

Common Side Effects for Zilretta

Warnings for Zilretta