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Kenalog vs. Zilretta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Triamcinolone injection

(Kenalog)

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Zilretta

(triamcinolone)

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Summary for Kenalog

Prescription only

Triamcinolone injection (Kenalog) is a steroid injection that helps reduce inflammation in adults and children. The medication is used to treat many conditions, including allergies, skin conditions, multiple sclerosis, arthritis, and gout attacks. It's typically given as a shot into the muscle (intramuscular) or directly into the affected joint (intra-articular). Side effects are similar to other steroid medications and can include trouble sleeping, mood changes, and injection side reactions.

Indications for Kenalog

This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:

Pros and Cons for Kenalog

Pros

  • Available in multiple strengths
  • Can be injected directly into the joints to reduce inflammation
  • A dose can last for several weeks
  • Safe for children and adults

Cons

  • Not safe during pregnancy or breastfeeding
  • Can raise your risk for infections
  • Causes side effects like headache, mood swings, and weight gain
  • Has a risk for bone loss or fractures

Common Side Effects for Kenalog

  • Injection site reactions
  • Swelling
  • High blood pressure
  • High blood sugar
  • Muscle weakness
  • Stomach pain
  • Trouble sleeping
  • Changes in your mood
  • Headache
  • Acne
  • Weight gain

Warnings for Kenalog

  • Serious nervous system problems
  • Severe allergic reactions
  • Heart and kidney problems
  • Hormone effects
  • Greater risk of infections
  • Eye problems
  • Stomach problems
  • Bone problems
  • Changes in mood and behavior
  • Cancer

Summary for Zilretta

Prescription only

Zilretta (triamcinolone) is a steroid injection used to treat knee pain from osteoarthritis in adults. It works by reducing inflammation in the joint, helping to relieve pain and stiffness. The typical dose is 32 mg injected directly into the knee (intra-articular) by a healthcare professional. Some potential side effects include joint swelling, cough, and bruising where the medication is injected.

Indications for Zilretta

Pros and Cons for Zilretta

Pros

  • Injected directly into the affected knee joint
  • Single injection per treatment
  • Lasts up to 3 months or longer

Cons

  • Must be given by a trained healthcare professional
  • Unknown if safe during pregnancy or breastfeeding
  • Side effects include joint swelling and bruising at the injection site

Common Side Effects for Zilretta

  • Joint swelling (3%)
  • Bruising at the injection site (2%)
  • Sinus infection (2%)
  • Cough (2%)

Warnings for Zilretta

  • Serious nervous system problems
  • Severe allergic reactions
  • Greater risk of infections
  • Hormone effects
  • Heart and kidney problems
  • Eye problems
  • Stomach problems
  • Bone problems
  • Changes in mood and behavior

Prices with our coupons for Kenalog vs. Zilretta

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Triamcinolone1 vial / 1ml of 40mg/ml
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Zilretta1 kit / 32mg vial of 5ml
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