Key takeaways
Alendronate (Fosamax) and zoledronic acid (Reclast) are both bisphosphonates used to treat osteoporosis, but they have some key differences. Alendronate (Fosamax) is taken orally, either daily or weekly, and is available as a tablet, oral solution, or dissolvable tablet. In contrast, zoledronic acid (Reclast) is given as an intravenous (IV) infusion, typically once a year or once every two years, at a clinic or provider's office. Alendronate (Fosamax) requires you to stay upright and avoid eating for 30 minutes after taking it, while Reclast (zoledronic acid) does not have these restrictions. However, Reclast (zoledronic acid) can cause flu-like symptoms after the infusion, such as fever and chills, which usually resolve within a few days. Both medications can cause serious side effects like jaw problems and low calcium levels, but Reclast (zoledronic acid) also carries a risk of kidney damage, especially in those with pre-existing kidney issues. Alendronate (Fosamax) and Reclast (zoledronic acid) are both available in brand name and generic form.
