Compare Flutamide vs. Nilutamide
Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Flutamide (Eulexin) and Nilutamide (Nilandron) are both androgen receptor inhibitors used to treat metastatic prostate cancer. Flutamide is taken three times a day, while Nilutamide is taken once a day, making Nilutamide more convenient. Flutamide must be used with another hormonal medication that targets LHRH, whereas Nilutamide is often used with surgical or medical castration. Both medications can cause hot flashes and liver problems, but Nilutamide can also cause difficulty with night vision and serious lung issues. Flutamide can also cause diarrhea and has interactions with warfarin. Both medications are available as lower-cost generics.
- Flutamide (Eulexin)Nilutamide (Nilandron)
- Flutamide (Eulexin)Nilutamide (Nilandron)
Summary of Flutamide vs. Nilutamide
Summary for Androgen receptor inhibitorPrescription onlyFlutamide (Eulexin) is used to treat metastatic prostate cancer, meaning cancer that has spread to other parts of the body. It’s a form of hormonal therapy called an androgen receptor inhibitor or antiandrogen, that works to block testosterone in your body. Flutamide (Eulexin) is one of the recommended options for prostate cancer and is taken by mouth three times a day. It can cause hot flashes and lower your sex drive, which can be bothersome.
Summary for Androgen receptor inhibitorPrescription onlyNilutamide (Nilandron) is taken by mouth and used to treat metastatic prostate cancer, meaning cancer that has spread to other parts of the body. It’s a form of hormonal therapy called an androgen receptor inhibitor or antiandrogen, that works to block testosterone in your body. Nilutamide (Nilandron) is one of the recommended options for prostate cancer and is taken once a day. It can cause hot flashes and make it difficult for your eyes to adjust at night, which can be bothersome.
Indications of Flutamide vs. Nilutamide
Indications for•Metastatic prostate cancerIndications for•Metastatic prostate cancerPros and Cons of Flutamide vs. Nilutamide
Pros and Const for Androgen receptor inhibitorPros•Taken orally, so it’s not a medication you have to inject•One of the recommended options for metastatic prostate cancer•Usually only needs to be taken for a few weeks after starting a LHRH agonist•Available as a lower-cost generic medicationCons•Taken 3 times a day•Can cause hot flashes, which can be unpleasant•Can cause liver problems•Can raise your risk for bleeds if you're taking a blood thinner called warfarin (Coumadin)Pros and Const for Androgen receptor inhibitorPros•Oral pill•Taken once daily•One of the recommended options for metastatic prostate cancer•Available as a lower-cost generic medicationCons•Can cause hot flashes, which can be unpleasant•Your eyes might start having problems adjusting to light•Can cause liver or breathing problemsCommon Side Effects of Flutamide vs. Nilutamide
Common Side Effects forPlease note: These side effects were experienced by people taking flutamide (Eulexin) with a LHRH agonist, and might not be caused by flutamide (Eulexin) alone.
•Hot flashes (61%)•Loss of sex drive (36%)•Erectile dysfunction (33%)•Diarrhea (12%)•Nausea and vomiting (11%)•Development of breasts (9%)Common Side Effects forSide effects experienced by people who took nilutamide (Nilandron) after surgical castration:
•Hot flashes (28%)•Difficulty of eyes adjusting to dark (13%)•Nausea (10%)•Pain or burning while urinating, needing to urinate more often, and other symptoms of a urinary tract infection (8%)Side effects experienced by people who took nilutamide (Nilandron) with leuprolide (a LHRH agonist):
•Hot flashes (67%)•Difficulty of eyes adjusting to dark (57%)•Nausea (24%)•Constipation (20%)•Weakness (20%)•Shrinking of testicles (16%)•Trouble sleeping (16%)•Headache (14%)Warnings of Flutamide vs. Nilutamide
Common Side Effects for•Severe liver damage•Bleeding with warfarin (Coumadin)•Possibly toxicityCommon Side Effects for•Rare, serious lung condition•Liver injuryPrices with our coupons for Flutamide vs. Nilutamide
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