Key takeaways
Xtandi (enzalutamide) and nilutamide (Nilandron) are both oral medications used to treat metastatic prostate cancer, but they have some differences. Both medications are taken by mouth once a day, but nilutamide is typically only taken for a few weeks after starting a LHRH agonist. Common side effects while on Xtandi are weakness and back pain, while those taking nilutamide commonly experience hot flashes, difficulty with night vision, and nausea. Xtandi can increase the risk of seizures and heart problems, whereas nilutamide has the risk of serious liver and lung problems. While Xtandi is only available as a brand-name medication, nilutamide is available as a lower-cost generic option.
