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Erleada vs. Xtandi

Erleada (apalutamide) is a prescription pill used to treat certain types of prostate cancer in adults. It’s usually taken along with other hormone treatments or after you’ve had surgery to remove the testicles. You take it once a day by mouth, with or without food. Erleada (apalutamide) works by blocking testosterone, which helps slow the growth of prostate cancer. Common side effects include tiredness, joint pain, and rash.

• Metastatic prostate cancer that's hormone-sensitive
• Non-metastatic prostate cancer that's castration-resistant

Metastatic prostate cancer:

• Rash (28%)
• Hot flashes (23%)
• High blood pressure (18%)
• Join pain (17%)
• Itchiness (11%)

Non-metastatic prostate cancer:

• Tiredness (39%)
• Rash (25%)
• High blood pressure (25%)
• Diarrhea (20%)
• Nausea (18%)
• Joint pain (16%)
• Weight loss (16%)
• Fall (16%)
• Hot flashes (14%)
• Fracture (12%)
• Reduced appetite (12%)
• Swelling in arms and legs (11%)

• Heart attack and stroke
• Falls and fractures
• Seizures
• Severe skin reactions
• Lung problems
• Harm to unborn baby

Xtandi (enzalutamide) is a prescription cancer medication used to treat certain types of prostate cancer in adults. It works by blocking testosterone, a hormone that many prostate cancers need to grow. You usually take a tablet or capsule once a day by mouth, often along with other hormone treatments or after surgery to remove the testicles. Common side effects include weakness or fatigue, back pain, and hot flashes.

• Prostate cancer that's castration-resistant
• Metastatic prostate cancer that's hormone-sensitive
• Non-metastatic prostate cancer that's hormone-sensitive, with a high risk of spreading

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Reduced appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

• Seizures
• Brain problem
• Allergic reaction
• Heart problems
• Falls and fractures
• Possible harm to unborn baby
• Choking and trouble swallowing