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Compare Erleada vs. Xtandi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Erleada (apalutamide)
    Xtandi (enzalutamide)
  • Erleada (apalutamide)
    Xtandi (enzalutamide)

  • Summary of Erleada vs. Xtandi

    Summary for Androgen receptor inhibitor
    Prescription only

    Erleada (apalutamide) is a prescription pill used to treat certain types of prostate cancer in adults. It’s usually taken along with other hormone treatments or after you’ve had surgery to remove the testicles. You take it once a day by mouth, with or without food. Erleada (apalutamide) works by blocking testosterone, which helps slow the growth of prostate cancer. Common side effects include tiredness, joint pain, and rash.

    Summary for Androgen receptor inhibitor
    Prescription only

    Xtandi (enzalutamide) is a prescription cancer medication used to treat certain types of prostate cancer in adults. It works by blocking testosterone, a hormone that many prostate cancers need to grow. You usually take a tablet or capsule once a day by mouth, often along with other hormone treatments or after surgery to remove the testicles. Common side effects include weakness or fatigue, back pain, and hot flashes.

  • Indications of Erleada vs. Xtandi

    Indications for
    •Metastatic prostate cancer that's hormone-sensitive
    •Non-metastatic prostate cancer that's castration-resistant
    Indications for
    •Prostate cancer that's castration-resistant
    •Metastatic prostate cancer that's hormone-sensitive
    •Non-metastatic prostate cancer that's hormone-sensitive, with a high risk of spreading

  • Pros and Cons of Erleada vs. Xtandi

    Pros and Const for Androgen receptor inhibitor
    Pros
    •Pill that’s taken by mouth once a day
    •Recommended option for certain types of prostate cancer
    •Can take with or without food
    Cons
    •Can cause a rash, which can take several months to go away
    •Can raise your risk for seizures and fractures
    •Requires regular blood tests and monitoring
    Pros and Const for Androgen receptor inhibitor
    Pros
    •Pill that’s taken by mouth once a day
    •Can take with or without food
    •Recommended option for certain types of prostate cancer
    Cons
    •Interacts with many medications
    •Can raise your risk for seizures and fractures
    •Requires regular blood tests and monitoring

  • Common Side Effects of Erleada vs. Xtandi

    Common Side Effects for

    Metastatic prostate cancer:

    •Rash (28%)
    •Hot flashes (23%)
    •High blood pressure (18%)
    •Join pain (17%)
    •Itchiness (11%)

    Non-metastatic prostate cancer:

    •Tiredness (39%)
    •Rash (25%)
    •High blood pressure (25%)
    •Diarrhea (20%)
    •Nausea (18%)
    •Joint pain (16%)
    •Weight loss (16%)
    •Fall (16%)
    •Hot flashes (14%)
    •Fracture (12%)
    •Reduced appetite (12%)
    •Swelling in arms and legs (11%)
    Common Side Effects for
    •Muscle and joint pain
    •Feeling more tired than usual
    •Hot flashes
    •Constipation
    •Reduced appetite
    •Diarrhea
    •High blood pressure
    •Bleeding problems
    •Falls
    •Bone fractures
    •Headache

  • Warnings of Erleada vs. Xtandi

    Common Side Effects for
    •Heart attack and stroke
    •Falls and fractures
    •Seizures
    •Severe skin reactions
    •Lung problems
    •Harm to unborn baby
    Common Side Effects for
    •Seizures
    •Brain problem
    •Allergic reaction
    •Heart problems
    •Falls and fractures
    •Possible harm to unborn baby
    •Choking and trouble swallowing

  • Prices with our coupons for Erleada vs. Xtandi

    Learn more about Erleada
    Learn more about Xtandi

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