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Erleada vs. Nubeqa

Erleada (apalutamide) is a prescription pill used to treat certain types of prostate cancer in adults. It’s usually taken along with other hormone treatments or after you’ve had surgery to remove the testicles. You take it once a day by mouth, with or without food. Erleada (apalutamide) works by blocking testosterone, which helps slow the growth of prostate cancer. Common side effects include tiredness, joint pain, and rash.

• Metastatic prostate cancer that's hormone-sensitive
• Non-metastatic prostate cancer that's castration-resistant

Metastatic prostate cancer:

• Rash (28%)
• Hot flashes (23%)
• High blood pressure (18%)
• Join pain (17%)
• Itchiness (11%)

Non-metastatic prostate cancer:

• Tiredness (39%)
• Rash (25%)
• High blood pressure (25%)
• Diarrhea (20%)
• Nausea (18%)
• Joint pain (16%)
• Weight loss (16%)
• Fall (16%)
• Hot flashes (14%)
• Fracture (12%)
• Reduced appetite (12%)
• Swelling in arms and legs (11%)

• Heart attack and stroke
• Falls and fractures
• Seizures
• Severe skin reactions
• Lung problems
• Harm to unborn baby

Nubeqa (darolutamide) is a prescription medication used to treat certain types of prostate cancer in adults. You usually take it along with other hormone treatments, with chemotherapy, or after surgery to remove the testicles. As an androgen receptor inhibitor, it blocks testosterone from helping prostate cancer grow. You take the tablet by mouth twice a day with food. Common side effects include low white blood cell count, tiredness, and rash.

• Non-metastatic prostate cancer that's castration-resistant
• Metastatic prostate cancer that's hormone-sensitive, taken alone
• Metastatic prostate cancer that's hormone-sensitive, used together with a chemotherapy medication called docetaxel

Non-metastatic prostate cancer:

• Rise in liver enzymes (up to 23%)
• Lower white blood cell count (20%)
• Tiredness (16%)

Metastatic prostate cancer (when taken alone):

• Rise in liver enzymes (up to 32%)
• Lower white blood cell count (16%)

Metastatic prostate cancer (when taken with docetaxel):

• Lower red blood cell count (72%)
• Higher blood sugar levels (57%)
• Lower white blood cell count (up to 52%)
• Rise in liver enzymes (up to 40%)
• Low calcium levels (31%)
• Constipation (23%)
• Rash (20%)

• Heart problems
• Seizure
• Harm to unborn baby