Compare
Erleada vs. Zytiga

Erleada (apalutamide) is a prescription pill used to treat certain types of prostate cancer in adults. It’s usually taken along with other hormone treatments or after you’ve had surgery to remove the testicles. You take it once a day by mouth, with or without food. Erleada (apalutamide) works by blocking testosterone, which helps slow the growth of prostate cancer. Common side effects include tiredness, joint pain, and rash.

• Metastatic prostate cancer that's hormone-sensitive
• Non-metastatic prostate cancer that's castration-resistant

Metastatic prostate cancer:

• Rash (28%)
• Hot flashes (23%)
• High blood pressure (18%)
• Join pain (17%)
• Itchiness (11%)

Non-metastatic prostate cancer:

• Tiredness (39%)
• Rash (25%)
• High blood pressure (25%)
• Diarrhea (20%)
• Nausea (18%)
• Joint pain (16%)
• Weight loss (16%)
• Fall (16%)
• Hot flashes (14%)
• Fracture (12%)
• Reduced appetite (12%)
• Swelling in arms and legs (11%)

• Heart attack and stroke
• Falls and fractures
• Seizures
• Severe skin reactions
• Lung problems
• Harm to unborn baby

Abiraterone (Zytiga) is an oral medication used to treat certain types of prostate cancer. It's taken by mouth once a day. But you'll also have to take it with a steroid, which is typically taken once or twice a day. You might also need to take another medication that targets GnRH (gonadotropin-releasing hormone), unless you’ve had surgery to remove both testicles (bilateral orchiectomy). Some common side effects caused by abiraterone (Zytiga) include high blood pressure and swelling from fluid build up. Zytiga is available as lower-cost generics, but Yonsa currently isn't.

Prostate cancer that has spread to other parts of the body, in combination with a corticosteroid:

• Cancer that needs testosterone to grow (Zytiga only)
• Cancer that can still grow when there’s not much testosterone (Yonsa and Zytiga)

• Tiredness (39%)
• High blood pressure, with or without symptoms such as dizziness and headache (up to 37%)
• Joint swelling or discomfort (30%)
• Muscle discomfort (26%)
• Swelling in your body from fluid buildup (edema) (27%)
• Constipation (23%)
• Diarrhea (up to 22%)
• Hot flash (up to 22%)

• Swelling from fluid buildup, heart problems, and low potassium levels
• Low stress hormone levels
• Liver damage
• Harm to unborn baby
• Low blood sugar