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Compare Erleada vs. Zytiga

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Erleada (apalutamide)
    Abiraterone (Zytiga)
  • Erleada (apalutamide)
    Abiraterone (Zytiga)

  • Summary of Erleada vs. Zytiga

    Summary for Androgen receptor inhibitor
    Prescription only

    Erleada (apalutamide) is a prescription pill used to treat certain types of prostate cancer in adults. It’s usually taken along with other hormone treatments or after you’ve had surgery to remove the testicles. You take it once a day by mouth, with or without food. Erleada (apalutamide) works by blocking testosterone, which helps slow the growth of prostate cancer. Common side effects include tiredness, joint pain, and rash.

    Summary for Androgen synthesis inhibitor
    Prescription only

    Abiraterone (Zytiga) is an oral medication used to treat certain types of prostate cancer. It's taken by mouth once a day. But you'll also have to take it with a steroid, which is typically taken once or twice a day. You might also need to take another medication that targets GnRH (gonadotropin-releasing hormone), unless you’ve had surgery to remove both testicles (bilateral orchiectomy). Some common side effects caused by abiraterone (Zytiga) include high blood pressure and swelling from fluid build up. Zytiga is available as lower-cost generics, but Yonsa currently isn't.

  • Indications of Erleada vs. Zytiga

    Indications for
    •Metastatic prostate cancer that's hormone-sensitive
    •Non-metastatic prostate cancer that's castration-resistant
    Indications for

    Prostate cancer that has spread to other parts of the body, in combination with a corticosteroid:

    •Cancer that needs testosterone to grow (Zytiga only)
    •Cancer that can still grow when there’s not much testosterone (Yonsa and Zytiga)

  • Pros and Cons of Erleada vs. Zytiga

    Pros and Const for Androgen receptor inhibitor
    Pros
    •Pill that’s taken by mouth once a day
    •Recommended option for certain types of prostate cancer
    •Can take with or without food
    Cons
    •Can cause a rash, which can take several months to go away
    •Can raise your risk for seizures and fractures
    •Requires regular blood tests and monitoring
    Pros and Const for Androgen synthesis inhibitor
    Pros
    •Oral pill, taken once daily
    •Recommended option for certain types of prostate cancer
    •Zytiga is available as a lower-cost generic
    Cons
    •Must be taken with a steroid
    •Can raise your blood pressure or cause fluid buildup
    •Zytiga needs to be taken on an empty stomach

  • Common Side Effects of Erleada vs. Zytiga

    Common Side Effects for

    Metastatic prostate cancer:

    •Rash (28%)
    •Hot flashes (23%)
    •High blood pressure (18%)
    •Join pain (17%)
    •Itchiness (11%)

    Non-metastatic prostate cancer:

    •Tiredness (39%)
    •Rash (25%)
    •High blood pressure (25%)
    •Diarrhea (20%)
    •Nausea (18%)
    •Joint pain (16%)
    •Weight loss (16%)
    •Fall (16%)
    •Hot flashes (14%)
    •Fracture (12%)
    •Reduced appetite (12%)
    •Swelling in arms and legs (11%)
    Common Side Effects for
    •Tiredness (39%)
    •High blood pressure, with or without symptoms such as dizziness and headache (up to 37%)
    •Joint swelling or discomfort (30%)
    •Muscle discomfort (26%)
    •Swelling in your body from fluid buildup (edema) (27%)
    •Constipation (23%)
    •Diarrhea (up to 22%)
    •Hot flash (up to 22%)

  • Warnings of Erleada vs. Zytiga

    Common Side Effects for
    •Heart attack and stroke
    •Falls and fractures
    •Seizures
    •Severe skin reactions
    •Lung problems
    •Harm to unborn baby
    Common Side Effects for
    •Swelling from fluid buildup, heart problems, and low potassium levels
    •Low stress hormone levels
    •Liver damage
    •Harm to unborn baby
    •Low blood sugar
    •Risk factors: High blood sugar that’s treated with certain medication

  • Prices with our coupons for Erleada vs. Zytiga

    Learn more about Erleada
    Learn more about Abiraterone

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