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Nubeqa vs. Xtandi

Nubeqa (darolutamide) is a prescription medication used to treat certain types of prostate cancer in adults. You usually take it along with other hormone treatments, with chemotherapy, or after surgery to remove the testicles. As an androgen receptor inhibitor, it blocks testosterone from helping prostate cancer grow. You take the tablet by mouth twice a day with food. Common side effects include low white blood cell count, tiredness, and rash.

• Non-metastatic prostate cancer that's castration-resistant
• Metastatic prostate cancer that's hormone-sensitive, taken alone
• Metastatic prostate cancer that's hormone-sensitive, used together with a chemotherapy medication called docetaxel

Non-metastatic prostate cancer:

• Rise in liver enzymes (up to 23%)
• Lower white blood cell count (20%)
• Tiredness (16%)

Metastatic prostate cancer (when taken alone):

• Rise in liver enzymes (up to 32%)
• Lower white blood cell count (16%)

Metastatic prostate cancer (when taken with docetaxel):

• Lower red blood cell count (72%)
• Higher blood sugar levels (57%)
• Lower white blood cell count (up to 52%)
• Rise in liver enzymes (up to 40%)
• Low calcium levels (31%)
• Constipation (23%)
• Rash (20%)

• Heart problems
• Seizure
• Harm to unborn baby

Xtandi (enzalutamide) is a prescription cancer medication used to treat certain types of prostate cancer in adults. It works by blocking testosterone, a hormone that many prostate cancers need to grow. You usually take a tablet or capsule once a day by mouth, often along with other hormone treatments or after surgery to remove the testicles. Common side effects include weakness or fatigue, back pain, and hot flashes.

• Prostate cancer that's castration-resistant
• Metastatic prostate cancer that's hormone-sensitive
• Non-metastatic prostate cancer that's hormone-sensitive, with a high risk of spreading

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Reduced appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

• Seizures
• Brain problem
• Allergic reaction
• Heart problems
• Falls and fractures
• Possible harm to unborn baby
• Choking and trouble swallowing