Key takeaways
Fluticasone nasal spray (Flonase, Flonase Sensimist) and Claritin-D (loratadine/pseudoephedrine) are both used to treat allergy symptoms, but they belong to different medication classes. Fluticasone is a corticosteroid that reduces inflammation in the nose, while Claritin-D combines an antihistamine (loratadine) and a decongestant (pseudoephedrine) to relieve allergy symptoms and congestion. Fluticasone is available as a nasal spray, either by prescription or over-the-counter, and is used daily. Claritin-D is an oral tablet available over-the-counter, with 12-hour and 24-hour formulations. Fluticasone can be used in children as young as 2 years old, while Claritin-D is only for those 12 and older. Common side effects of fluticasone include headache and nosebleeds, whereas Claritin-D may cause headache, dry mouth, and trouble sleeping. You should avoid taking other antihistamines or decongestants with Claritin-D to prevent overdose, while fluticasone requires caution if you have nasal injuries or eye problems.
