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Compare Femring vs. Estring

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Femring (estradiol)
Estring (estradiol)
Femring (estradiol)
Estring (estradiol)

Summary of Femring vs. Estring

Summary for Estrogen replacement
Prescription only

Femring (estradiol) is a type of estrogen replacement that comes as a vaginal ring. This hormonal replacement therapy (HRT) is used to treat symptoms of menopause, such as hot flashes and vaginal dryness. The usual dosage is to insert 1 ring into the vagina every 3 months. Common side effects include vaginal bleeding and breast tenderness.

Summary for Estrogen replacement
Prescription only

Estring (estradiol) is an estrogen vaginal ring used as part of hormone replacement therapy (HRT) to treat moderate-to-severe menopause symptoms in and around the vagina, such as vaginal dryness, burning, and irritation. The ring is inserted into the vagina and stays in place for 3 months, releasing a steady dose of estrogen directly where it's needed. Common side effects include headache, vaginal discharge, and vaginal yeast infections.

Indications of Femring vs. Estring

Indications for
•Moderate-to-severe vasomotor symptoms of menopause, such as hot flashes and night sweats
•Moderate-to-severe vaginal dryness, burning, and irritation caused by menopause
Indications for
•Vaginal dryness, burning, and irritation due to menopause

Pros and Cons of Femring vs. Estring

Pros and Const for Estrogen replacement
Pros
•Relieves both vaginal symptoms and hot flashes due to menopause
•Might be more comfortable and easier to use than vaginal creams
•Only need to change the ring every 3 months
Cons
•Can sometimes cause vaginal yeast infections
•Might take a few weeks before you start to feel symptom improvement
•Must take an additional hormonal medication called a progestin if you have your uterus to lower your risk for uterine cancer
Pros and Const for Estrogen replacement
Pros
•Can be inserted by you or a healthcare professional
•Only needs to be changed every 3 months
•Works directly at the site of application to relieve vaginal symptoms
Cons
•Can cause vaginal yeast infections
•Doesn't treat other menopause symptoms like hot flashes or night sweats
•Must take a progestin if you have a uterus to lower your risk of uterine cancer

Common Side Effects of Femring vs. Estring

Common Side Effects for
•Breast tenderness (6-11%)
•Vaginal yeast infections (6-11%)
•Vaginal spotting (8-10%)
•Headache (7-10%)
•Stomach bloating (3-7%)
•Back pain (4-6%)
Common Side Effects for
•Headache (13%)
•Vaginal discharge (7%)
•Vaginal yeast infection (6%)
•Back pain (6%)
•Vaginal inflammation (5%)
•Vaginal discomfort or pain (5%)
•Upper respiratory infection (5%)
•Vaginal bleeding (4%)
•Bacterial growth in the vagina (4%)
•Arthritis (4%)
•Trouble sleeping (4%)
•Stomach pain (4%)
•Sinus inflammation (4%)
•Nausea (3%)
•Flu-like symptoms (3%)
•Joint pain (3%)

Warnings of Femring vs. Estring

Common Side Effects for
•Risk for blood clots and related complications
•Risk for uterine cancer (also called endometrial cancer)
•Risk for breast cancer
•Risk for ovarian cancer
•Risk for dementia
•Gallbladder or liver problems in certain people
•High triglyceride (fat) levels
•Changes in calcium levels in certain people
•Low thyroid hormone levels
•Buildup of fluids in your body (fluid retention)
•Worsening of certain other health conditions
•Risks related to vaginal use
Common Side Effects for
•Risk for blood clots and related complications
•Risk for uterine cancer (also called endometrial cancer)
•Risk for breast cancer
•Risk for ovarian cancer
•Risk for dementia
•Gallbladder or liver problems in certain people
•High triglyceride (fat) levels
•Changes in calcium levels in certain people
•Low thyroid hormone levels
•Buildup of fluids in your body (fluid retention)
•Worsening of certain other health conditions
•Vaginal irritation and infections

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