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Evenity vs. Alendronate

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh

Alendronate sodium (Fosamax) is a bisphosphonate that prevents and treats osteoporosis. It works by slowing the breakdown of bones so that the body has a chance to build up more bone; this strengthens bones and lowers the risk of fractures. Alendronate (Fosamax) is taken by mouth, either daily or weekly dosing, depending on your dose. In addition to the tablet, it's also available as an oral solution and a dissolvable tablet (brand name Binosto). Some common side effects of alendronate (Fosamax) can include stomach pain, heartburn, and bone or muscle pain.

• Prevention and treatment of osteoporosis in females
• Treatment of osteoporosis in males
• Paget's disease

• Stomach pain (up to 7%)
• Muscle, bone, and joint pain (up to 4%)
• Heartburn or indigestion (up to 4%)
• Nausea (up to 4%)
• Passing gas (up to 4%, more common with daily dose)

• Irritation and ulcers of the stomach and esophagus
• Lower calcium levels
• Muscle Pain
• Jaw bone problems
• Leg bone fractures
• Not recommended in people with serious kidney problems