Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Entresto vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril/valsartan) and lisinopril (Zestril) are both medications used to treat heart failure, but they belong to different drug classes. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI), while lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Entresto is specifically approved for heart failure in adults and children over 1 year old, whereas lisinopril is also approved for high blood pressure and to lower the risk of death after a heart attack. Entresto is taken twice daily as tablets or oral pellets, while lisinopril is typically taken once daily and comes as a tablet or liquid. Entresto only comes as a branded medication, while lisinopril is available as a lower-cost generic. Common side effects of Entresto include low blood pressure, high potassium levels, and dizziness, while lisinopril can cause dizziness, low blood pressure, and a dry cough. Both medications can interact with other drugs, so be sure your prescriber and pharmacist have a complete list of your medications.

  • Entresto (sacubitril / valsartan)
    Lisinopril (Zestril)
  • Entresto (sacubitril / valsartan)
    Lisinopril (Zestril)

  • Summary of Entresto vs. Lisinopril

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for ACE inhibitor
    Prescription only

    Lisinopril (Zestril) is an angiotensin-converting enzyme inhibitor, or ACE inhibitor. It's used to treat high blood pressure in people 6 years and older. In adults, it's also approved to manage heart failure and to lower the risk of death after a heart attack. Lisinopril (Zestril) comes as a tablet that's taken by mouth once daily. There's also an oral solution available under the brand name Qbrelis. Some side effects include dizziness, cough, and headache.

  • Indications of Entresto vs. Lisinopril

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •High blood pressure in people ages 6 years and older
    •Heart failure in adults
    •Lowering the risk of death after a heart attack in adults

  • Pros and Cons of Entresto vs. Lisinopril

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for ACE inhibitor
    Pros
    •Taken by mouth once per day
    •A first-choice medication for high blood pressure
    •Also helpful for heart failure and after a heart attack
    •Okay for children as young as 6 years old to take to treat high blood pressure
    Cons
    •More likely to cause dry cough than ARBs
    •Can make you feel dizzy, especially at first
    •Might not work as well for lowering blood pressure in Black people
    •Not safe during pregnancy

  • Common Side Effects of Entresto vs. Lisinopril

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Dizziness (up to 19%)
    •Low blood pressure (up to 11%)
    •Higher creatinine levels (up to 10%)

  • Warnings of Entresto vs. Lisinopril

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Harm to an unborn baby
    •Angioedema (swelling)
    •Low blood pressure
    •Possible worsening of kidney problems
    •High potassium levels
    •Liver problems

  • Prices with our coupons for Entresto vs. Lisinopril

    Learn more about Entresto
    Learn more about Lisinopril

Compare other Heart Failure drugs

Entresto vs FarxigaEntresto vs JardianceEntresto vs LisinoprilEntresto vs LosartanEntresto vs RanexaEntresto vs ValsartanVasotec vs EntrestoVerquvo vs EntrestoAmlodipine vs LosartanEdarbi vs LosartanEnalapril vs LosartanLabetalol vs LosartanLosartan vs AtenololLosartan vs BetapaceLosartan vs BisoprololLosartan vs CatapresLosartan vs HydrochlorothiazideLosartan vs LisinoprilLosartan vs Lotensin HctLosartan vs MetoprololLosartan vs NifedipineMavik vs LosartanMonopril vs LosartanPropranolol vs LosartanVasotec vs AltaceVasotec vs LotensinVasotec vs PrinivilVasotec vs QbrelisVasotec vs TenorminVasotec vs Zestril
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.