Key takeaways
Amitriptyline (formerly branded as Elavil) and doxepin (formerly branded as Sinequan) are both tricyclic antidepressants (TCAs) used to treat depression. However, doxepin is also FDA approved for anxiety, while amitriptyline is often used off-label for nerve pain and migraine prevention. Both medications can cause sleepiness and weight gain, but amitriptyline has a higher risk of interactions with other medications, such as sedatives and antihistamines. Doxepin is available in an oral solution form, which can be helpful if you have trouble swallowing pills. Both medications can cause withdrawal symptoms if stopped suddenly, and they are not recommended for people with certain heart conditions or glaucoma. Additionally, both can worsen mood symptoms, especially in younger individuals.
