Key takeaways
Phenytoin (Dilantin) and fosphenytoin (Cerebyx) are both antiepileptic medications used to treat and prevent various types of seizures, including those during and after brain surgery, but they have some key differences. Phenytoin is available in capsules, chewable tablets, liquid, and injection, while fosphenytoin is an injectable medication typically given by a healthcare professional. Both are available as low-cost generics. Fosphenytoin is converted into phenytoin in the body and used when you can't take oral medications. Because of this, side effects are similar between both medications and include dizziness, sleepiness, and uncontrolled eye movements. Both medications can cause serious side effects, including heart problems and severe allergic reactions, but fosphenytoin has additional risks like "purple glove syndrome," where there is purple-bluish discoloration, swelling, and pain at the injection site.
