Skip to main content

Compare
Cyclobenzaprine vs. Tramadol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cyclobenzaprine and tramadol are both medications used to manage pain, but they belong to different classes and have distinct uses. Cyclobenzaprine is a muscle relaxant used to treat muscle pain and discomfort, while tramadol is an opioid used for pain that isn't relieved by non-opioid medications. Cyclobenzaprine is available as immediate-release tablets and extended-release capsules, and it's not a controlled substance. In contrast, tramadol is a Schedule IV controlled substance available in immediate-release and extended-release forms. Cyclobenzaprine is typically taken up to three times a day, whereas tramadol's dosing varies based on the form and individual needs. Cyclobenzaprine can cause drowsiness and dry mouth, and Tramadol, on the other hand, can cause constipation, nausea, and serious risks like slow breathing and dependency. Both medications may interact with medications that affect serotonin levels, leading to serotonin syndrome. Tramadol requires careful monitoring due to its potential for misuse.

Cyclobenzaprine

 

Get free coupons

Tramadol

 

Get free coupons

Summary for Cyclobenzaprine

Prescription only

Cyclobenzaprine is a muscle relaxant that helps relieve muscle pain and discomfort. It's often used short term with rest and physical therapy. Immediate-release tablets are for people 15 years and older and are taken a few times a day. Once sold under the brand name Flexeril, the tablets now as a generic and brand name Fexmid. Extended-release capsules are for adults only and are taken once a day. The capsules comes as a generic and brand name Amrix. Cyclobenzaprine can make you sleepy and have dry mouth as side effects.

Indications for Cyclobenzaprine

  • Muscle discomfort from short-term muscle or bone injury problems

Pros and Cons for Cyclobenzaprine

Pros

  • Can take with or without food
  • Available as short-acting and long-acting forms for flexible dosing schedules
  • Can help with recovery from acute painful muscle problems in a few days

Cons

  • Only meant for short-term use (up to 2 to 3 weeks at a time)
  • Might not be a safe option for older adults
  • Not known to work well for nerve pain or muscle spasms caused by brain or spinal injuries

Common Side Effects for Cyclobenzaprine

Immediate-release tablets:

  • Drowsiness (39%)
  • Dry mouth (27%)
  • Dizziness (11%)

Extended-release capsules:

  • Dry mouth (14%)
  • Dizziness (6%)

Warnings for Cyclobenzaprine

  • Serotonin syndrome
  • Effect on driving and concentration
  • Caution use in people with glaucoma or trouble urinating
  • Caution use in people with liver problems

Summary for Tramadol

Prescription only

Tramadol is an opioid pain medication used when non-opioid medications aren't working well enough to control pain. Compared to other opioids, tramadol might have a lower risk of misuse and dependency. But tramadol is a controlled substance and has a lot of potentially serious risks, so it must be used with caution.

Indications for Tramadol

  • Pain that isn't relieved by non-opioid pain medications alone

Pros and Cons for Tramadol

Pros

  • Extended-release tablets and ConZip capsules are taken once per day and last throughout the day.
  • Immediate-release tablets are available as a lower-cost generic.
  • Possible lower risk of misuse and dependency compared to other opioids

Cons

  • A controlled medication, so there are special requirements to get a prescription filled
  • Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms
  • Can't use in some children due to higher risk of potentially severe and life-threatening side effects
  • Not recommended while breastfeeding

Common Side Effects for Tramadol

  • Constipation (up to 46%)
  • Nausea (up to 40%)
  • Dizziness (up to 33%)
  • Headache (up to 32%)
  • Sleepiness (up to 25%)
  • Vomiting (up to 17%)

Warnings for Tramadol

  • Potential for addiction and misuse
  • Dangerously slow breathing (respiratory depression)
  • Overdose
  • Harm to newborn babies
  • Drug interactions
  • Difficulty concentrating and extreme sleepiness
  • Serotonin syndrome
  • Seizures
  • Low blood pressure
  • Low adrenal hormone levels
  • Physical dependence and withdrawal
  • Low blood sodium levels

Prices with our coupons for Cyclobenzaprine vs. Tramadol

Price Card Drug Icon
Cyclobenzaprine30 tablets / 10mg
$10.14-
Get free coupons
More Information
Price Card Drug Icon
Tramadol60 tablets / 50mg
$11.42$22.11
Get free coupons
More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.