Key takeaways
Varenicline (Chantix) and bupropion (Wellbutrin XL, Wellbutrin SR) are both medications used to help people quit smoking, although this is an off-label use for bupropion. There are some differences between them. Varenicline is a partial nicotine agonist, while bupropion is an atypical antidepressant. Varenicline is specifically FDA-approved for smoking cessation, whereas bupropion is approved for depression and seasonal affective disorder (SAD). Varenicline is taken orally, starting with a low dose that gradually increases over the first week, and is typically used for 12 weeks. Bupropion is available in immediate-release, sustained-release, and extended-release forms, with dosing varying based on the formulation. Generic versions of both medications are available. Common side effects of varenicline include nausea and vivid dreams, while bupropion may cause dry mouth and trouble sleeping. Varenicline can interact with alcohol, increasing its effects, while bupropion can raise the risk of seizures, especially if you have a history of seizures or eating disorders.
