Key takeaways
Cefazolin (Ancef) and cephalexin (Keflex) are both cephalosporin antibiotics used to treat bacterial infections. They share some common uses, such as treating respiratory tract infections, skin infections, and urinary tract infections (UTIs). However, they differ in several ways. Cefazolin is a first-generation cephalosporin available only as an injection, typically administered in a hospital setting, while cephalexin is available in oral forms like capsules, tablets, and liquid suspensions, making it more convenient for home use. Cefazolin is often used for more severe infections and surgical infection prevention, whereas cephalexin is commonly used for milder infections, including ear and sinus infections. Both medications are available as a lower-cost generic. Both medications can cause side effects like diarrhea and allergic reactions. Additionally, they can both can interact with probenecid and require dose adjustments for people with kidney problems.
