Key takeaways
Cefadroxil (Duricef) and cephalexin (Keflex) are both cephalosporin antibiotics used to treat bacterial infections, including urinary tract and skin infections. They share a similar mechanism of action by preventing bacteria from forming a protective covering. However, they differ in several ways. Cefadroxil is typically taken once or twice a day, while cephalexin is taken 2 to 4 times a day. Both medications are available as affordable generics and come in tablets, capsules, and liquid suspensions. Common side effects for both include diarrhea, nausea and vomiting. Both medications may interact with probenacid, while cephalexin also has an interaction with metformin listed. Additionally, cephalexin is used for a broader range of infections, including respiratory and ear infections, which are not listed for cefadroxil.
