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Buspar vs. Lexapro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Buspirone (Buspar) and escitalopram (Lexapro) are both medications that can be used to treat anxiety, but they have some important differences. Buspirone is an antianxiety medication, while escitalopram is a selective serotonin reuptake inhibitor (SSRI) that is also FDA-approved for treating depression. Buspirone is typically taken twice a day, whereas escitalopram is taken once daily. Buspirone is available only as a generic, while escitalopram is available in both brand and generic forms. Common side effects of buspirone include dizziness and headache, while escitalopram can cause nausea and trouble sleeping. Escitalopram can cause withdrawal symptoms if stopped suddenly, while buspirone has a low risk of withdrawal. Additionally, buspirone interacts with many medications and grapefruit juice, while escitalopram has fewer interactions but can increase the risk of bleeding when taken with certain medications.

Buspirone

 

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Escitalopram

(Lexapro)

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Summary for Buspar

Prescription only

Buspirone tablets help manage and relieve anxiety in adults. It belongs to a drug class called anxiolytics (or anti-anxiety medications). The tablets are taken by mouth, typically twice daily. Common side effects are dizziness, nausea, headache, and nervousness. Buspirone isn't a controlled substance. The brand name Buspar is no longer available, but you can get the generic buspirone tablets.

Indications for Buspar

Pros and Cons for Buspar

Pros

Cons

Common Side Effects for Buspar

  • Dizziness (12%)
  • Drowsiness (10%)
  • Nausea (8%)
  • Headache (6%)
  • Nervousness (5%)

Warnings for Buspar

  • Serotonin syndrome
  • Effect on driving and concentration
  • Not safe with monoamine oxidase inhibitors (MAOIs)
  • Doesn't help relieve withdrawal symptoms from other anxiety medications

Summary for Lexapro

Prescription only

Escitalopram, also known by its brand name, Lexapro, is a selective serotonin reuptake inhibitor (SSRI). It's a first-choice antidepressant to treat depression and anxiety in adults and children. The medication is available as a tablet and oral solution, in both brand and generic forms. A dose is typically taken by mouth once per day. Some common side effects include nausea, trouble sleeping (insomnia), and dizziness.

Indications for Lexapro

Pros and Cons for Lexapro

Pros

  • First-choice medication for anxiety and depression
  • Only need to take it once a day
  • Generally has fewer side effects compared to other antidepressants
  • Can be taken with or without food

Cons

  • Can take up to 2 months before you feel the the full benefits
  • Risk of certain sexual problems
  • Can raise your risk for bleeds
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Lexapro

  • Headache (24%)
  • Nausea (15-18%)
  • Ejaculation problems (9-14%)
  • Sleepiness (6-13%)
  • Trouble sleeping (9-12%)
  • Dry mouth (6-9%)
  • Diarrhea (8%)
  • Tiredness (5-8%)

Warnings for Lexapro

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Stopping escitalopram (Lexapro) too suddenly
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels
  • Sexual problems

Prices with our coupons for Buspar vs. Lexapro

Price Card Drug Icon
Buspirone60 tablets / 10mg
$9.00$9.00
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Escitalopram30 tablets / 10mg
$9.51$17.33
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