Key takeaways
Bupropion (Wellbutrin XL, Wellbutrin SR) and escitalopram (Lexapro) are both medications used to treat depression. However, they belong to different medication classes and have distinct characteristics. Bupropion is an atypical antidepressant that also treats seasonal affective disorder (SAD) and works by boosting norepinephrine and dopamine levels in the brain. In contrast, escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels and is also used for generalized anxiety disorder (GAD). Bupropion is available in various formulations, including immediate-release, sustained-release, and extended-release tablets, while escitalopram is available as a tablet and oral solution. Bupropion is typically taken once or multiple times a day, depending on the formulation, whereas escitalopram is taken once daily. Bupropion is less likely to cause weight gain and sexual side effects but can increase the risk of seizures, especially in people with a history of seizures or eating disorders. Escitalopram, on the other hand, can cause sexual side effects and may lead to serotonin syndrome if taken with other medications that increase serotonin. Both medications can cause withdrawal symptoms, especially if stopped suddenly.
