Key takeaways
Trintellix (vortioxetine) and Pristiq (desvenlafaxine) are both medications used to treat depression in adults. Both medications may help improve mood by affecting serotonin levels in the brain. However, they belong to different medication classes. Trintellix is an atypical antidepressant, while Pristiq is a serotonin and norepinephrine reuptake inhibitor (SNRI). Trintellix is typically started at a dose of 10 mg once daily, whereas Pristiq is usually taken at a dose of 50 mg once daily. Trintellix is only available as a brand-name medication, while Pristiq has a lower-cost generic option. Common side effects of Trintellix include nausea and diarrhea, while Pristiq may cause nausea and dizziness. Both medications can lead to serotonin syndrome if taken with other drugs that increase serotonin levels, but Pristiq can also raise blood pressure, which may be a concern if you have heart problems.
