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Breztri vs. Anoro Ellipta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) and Anoro Ellipta (umeclidinium/vilanterol) are both inhaled medications used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. However, they differ in several ways. Breztri Aerosphere is a combination of three medications: an inhaled corticosteroid (ICS), a long-acting muscarinic antagonist (LAMA), and a long-acting beta agonist (LABA). In contrast, Anoro Ellipta combines only a LAMA and a LABA, and it does not contain a steroid. Breztri is taken as two inhalations twice daily, while Anoro Ellipta is taken as one inhalation once daily. Both medications are only available as brand-name medications. Common side effects of both medications include upper respiratory tract infections and pneumonia and should not be used for sudden breathing problems. You should have a rescue inhaler like albuterol on hand for such situations. Additionally, Breztri requires rinsing your mouth after use to prevent oral thrush, a step not needed with Anoro Ellipta.

Breztri

 

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Anoro Ellipta

(umeclidinium / vilanterol)

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Summary for Breztri

Prescription only

Breztri Aerosphere is a combination inhaler that contains budesonide (an inhaled corticosteroid), glycopyrrolate (a long-acting muscarinic antagonist), and formoterol fumarate (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Breztri is inhaled through the mouth and into the lungs twice per day every day. The most common side effects are upper respiratory tract infections and pneumonia. Breztri is brand name only and not available as a lower-cost generic.

Indications for Breztri

Pros and Cons for Breztri

Pros

  • Lowers the risk of COPD flare-ups
  • Combination of three medications in a single inhaler
  • Can be used with a spacer to make it easier to take a dose

Cons

  • Need to rinse your mouth after each dose
  • Need to inhale 2 puffs twice daily
  • Doesn't treat sudden worsening symptoms of COPD

Common Side Effects for Breztri

Warnings for Breztri

  • Not for asthma, COPD flare ups, or worsening breathing
  • Fungal infection in the mouth
  • Narrowing of your airways (bronchospasm)
  • Allergic reactions
  • Higher risk of infections
  • Changes in stress hormone levels
  • Eye and vision problems
  • Heart problems
  • Low potassium levels in the blood
  • Trouble urinating

Summary for Anoro Ellipta

Prescription only

Anoro Ellipta is a steroid-free inhaler that contains umeclidinium (a long-acting muscarinic antagonist, or LAMA) and vilanterol (a long-acting beta agonist, or LABA). It's FDA-approved for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. This Ellipta inhaler is inhaled through the mouth once per day. Side effects aren't common, but some people have reported sore throat and diarrhea.

Indications for Anoro Ellipta

Pros and Cons for Anoro Ellipta

Pros

  • Combination of two bronchodilators within a single inhaler
  • Inhaled once per day
  • No need to rinse your mouth after a dose since it doesn't contain a steroid

Cons

  • Doesn't replace your rescue inhaler for sudden trouble breathing
  • Can't use if you're severely allergic to milk proteins because it contains lactose
  • Might not be a good choice for people who've trouble urinating

Common Side Effects for Anoro Ellipta

  • Sore throat (2%)
  • Diarrhea (2%)

Warnings for Anoro Ellipta

  • Not for COPD flare ups or worsening breathing
  • Narrowing of your airways (bronchospasm)
  • Serious allergic reactions
  • Worsening narrow-angle glaucoma
  • Trouble urinating
  • Heart problems
  • Low potassium level in the blood

Prices with our coupons for Breztri vs. Anoro Ellipta

Price Card Drug Icon
Breztri Aerosphere1 inhaler / 120 inhalations of 160mcg/9mcg/4.8mcg
$665.69$847.96
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Umeclidinium/Vilanterol Ellipta1 inhaler / 60 blisters of 62.5mcg/25mcg
$273.88$552.93
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